| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
,
,
*Department of Anesthesia, Stanford University School of Medicine, Stanford;
Anesthesiology Service, Veterans Administration Palo Alto Health Care System, Palo Alto, California; and
Magill Department of Anaesthetics, Imperial College School of Medicine, Chelsea and Westminster Campus, London, United Kingdom
Address correspondence and reprint requests to Dr. Masahiko Fujinaga, Magill Department of Anaesthetics, Imperial College School of Medicine, Chelsea and Westminster Campus, 369 Fulham Rd., London, SW10 9NH, UK. Address e-mail to m.fujinaga{at}ic.ac.uk
To study strain differences in antinociceptive effects of nitrous oxide (N2O), we examined various outbred and inbred stains of rats by using tail flick latency response. All outbred strains, i.e., Sprague-Dawley from two different breeders, Wistar, and Long-Evans, showed a similar antinociceptive response. Namely, the peak response occurred after 30 min of exposure, and tolerance to N2O developed within 60 to 90 min. Each of the four inbred stains examined, i.e., Wistar-Kyoto, Brown-Norway, Fischer, and Lewis, displayed a unique pattern of antinociceptive response to N2O. Wistar-Kyoto and Brown-Norway strains showed somewhat similar patterns as those observed in outbred strains, apart from the fact that the Wistar-Kyoto displayed a more distinct development of tolerance, whereas, the Brown-Norway strain had a lower peak effect. The Fischer strain displayed the greatest antinociceptive response to N2O, and did not develop tolerance. The Lewis strain showed no antinociceptive response to N2O. These results indicate differences in the durability and the magnitude of the antinociceptive response to N2O among various strains of rats.
Implications: Because of the variability that already exists, we recommend that animal studies examining the antinociceptive effects of nitrous oxide should be performed on inbred rat strains.
This article has been cited by other articles:
|
|
 |
|
  S. Koyanagi, S. Himukashi, K. Mukaida, T. Shichino, and K. Fukuda Dopamine D2-Like Receptor in the Nucleus Accumbens Is Involved in the Antinociceptive Effect of Nitrous Oxide Anesth. Analg., June 1, 2008; 106(6): 1904 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Antognini, R. J. Atherley, R. C. Dutton, M. J. Laster, E. I. Eger II, and E. Carstens The Excitatory and Inhibitory Effects of Nitrous Oxide on Spinal Neuronal Responses to Noxious Stimulation Anesth. Analg., April 1, 2007; 104(4): 829 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vahle-Hinz, O. Detsch, C. Hackner, and E. Kochs Corresponding minimum alveolar concentrations of isoflurane and isoflurane/nitrous oxide have divergent effects on thalamic nociceptive signalling Br. J. Anaesth., February 1, 2007; 98(2): 228 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. R. Lariviere, M. A. Sattar, and R. Melzack Inflammation-Susceptible Lewis Rats Show Less Sensitivity Than Resistant Fischer Rats in the Formalin Inflammatory Pain Test and With Repeated Thermal Testing J Neurophysiol, May 1, 2006; 95(5): 2889 - 2897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Eicher and J. W. Dailey Indicators of Acute Pain and Fly Avoidance Behaviors in Holstein Calves Following Tail-docking J Dairy Sci, November 1, 2002; 85(11): 2850 - 2858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sawamura, W. S. Kingery, M. F. Davies, G. S. Agashe, J. D. Clark, B. K. Kobilka, T. Hashimoto, and M. Maze Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of {alpha}2B Adrenoceptors J. Neurosci., December 15, 2000; 20(24): 9242 - 9251. [Abstract] [Full Text] [PDF]
|
|
|
