JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Maurer, A. J. Articles by Sonner, J. M. Search for Related Content PubMed PubMed Citation Articles by Maurer, A. J. Articles by Sonner, J. M.

---

GENERAL ARTICLES

The Nonimmobilizer 1,2-Dichlorohexafluorocyclobutane Does Not Affect Thermoregulation in the Rat

Department of Anesthesia and Perioperative Care, University of California, San Francisco, California

Address correspondence to James M. Sonner, MD, Department of Anesthesia, 513 Parnassus Ave., Box 0464, University of California, San Francisco, CA 94143-0464. Address e-mail to sonnerj{at}anesthesia .ucsf.edu.

Inhaled and other anesthetics profoundly affect the central nervous system, causing amnesia, immobility in the face of noxious stimulation, and depression of thermoregulation. Nonimmobilizers, inhaled compounds whose lipophilicity suggests that they should be anesthetics, do not produce immobility, but they do cause amnesia. Their effects on thermoregulation were the subject of the present study. We gave eight rats isoflurane on one occasion and the nonimmobilizer 2N (1,2-dichlorolhexafluorocyclobutane) on another. We measured the effect of various concentrations of each compound on thermoregulation provoked by body cooling. The specific outcome was increased metabolism, as reflected in increased output of carbon dioxide. Isoflurane decreased the temperature threshold for such increases and the maximum response intensity, doing so in a concentration-dependent manner, whereas 2N had a minimal or no effect at any concentration up to 0.9 minimum alveolar concentration (estimated from its lipophilicity). Thus, 2N may be a useful tool for studies of the mechanisms mediating the thermoregulatory depression produced by anesthetics: 2N should not affect such a mechanism.

Implications: Unlike inhaled anesthetics, the nonimmobilizer 2N (1,2-dichlorohexafluorocyclobutane) minimally affects temperature regulation in rats. Thus, 2N may be useful in mechanistic studies of temperature regulation. Cellular and molecular sites that mediate the capacity of inhaled anesthetics to depress thermoregulation should be influenced by anesthetics but not by 2N.

This article has been cited by other articles:

				A. Paris, C. Ohlendorf, M. Marquardt, B. Bein, J. M. Sonner, J. Scholz, and P. H. Tonner The Effect of Meperidine on Thermoregulation in Mice: Involvement of {alpha}2-Adrenoceptors Anesth. Analg., January 1, 2005; 100(1): 102 - 106. [Abstract] [Full Text] [PDF]

				E. I Eger II, Y. Xing, R. Pearce, S. Shafer, M. J. Laster, Y. Zhang, M. S. Fanselow, and J. M. Sonner Isoflurane Antagonizes the Capacity of Flurothyl or 1,2-Dichlorohexafluorocyclobutane to Impair Fear Conditioning to Context and Tone Anesth. Analg., April 1, 2003; 96(4): 1010 - 1018. [Abstract] [Full Text] [PDF]

				E. I Eger II, D. Gong, Y. Xing, D. E. Raines, and P. Flood Acetylcholine Receptors and Thresholds for Convulsions from Flurothyl and 1,2-Dichlorohexafluorocyclobutane Anesth. Analg., December 1, 2002; 95(6): 1611 - 1615. [Abstract] [Full Text] [PDF]

				C. M. Borghese and R. A. Harris Anesthetic-Induced Immobility: Neuronal Nicotinic Acetylcholine Receptors Are No Longer in the Picture Anesth. Analg., September 1, 2002; 95(3): 509 - 511. [Full Text] [PDF]

				C. H. Kindler, T. Girard, D. Gong, and A. Urwyler The Differential Effect of Halothane and 1,2-Dichlorohexafluorocyclobutane on In VitroMuscle Contractures of Patients Susceptible to Malignant Hyperthermia Anesth. Analg., April 1, 2002; 94(4): 1028 - 1033. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999