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Anesth Analg 2000;91:955-959
© 2000 International Anesthesia Research Society

REGIONAL ANESTHESIA AND PAIN MEDICINE

The Effects of KRN5500, a Spicamycin Derivative, on Neuropathic and Nociceptive Pain Models in Rats

Salahadin Abdi, MD, PhD*, Natalia Vilassova, MD*,{dagger}, Isabelle Decosterd, MD*, Nusrat Feroz, BS{dagger}, and David Borsook, MD, PhD{dagger}

Departments of *Anesthesia and Critical Care and {dagger}Radiology and Neurology, Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital, Charlestown, Massachusetts

Address correspondence and reprint requests to David Borsook MD, PhD, Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital, Bldg. 149, 13th St., Mail Code 2301, Charlestown, MA 02129-2060. Address e-mail to dborsook{at}nmr.mgh.harvard.edu

We studied the effects of a spicamycin derivative, KRN5500, on two animal models of neuropathic pain (Chung and Bennett models) and a nociceptive pain model by using Complete Freund’s adjuvant. After the establishment of mechanical allodynia by using the previously mentioned models, a single intraperitoneal injection of KRN5500 produced significant attenuation of mechanical allodynia in both neuropathic pain models. However, this effect was not observed in rats that had a nociceptive injury (Complete Freund’s adjuvant). Furthermore, this experimental drug did not alter the mechanical pain threshold (by using von Frey filament test) on normal, uninjured rats. We have demonstrated that KRN5500 may have value in the treatment of neuropathic pain.

Implications: Implications: We have demonstrated that KRN5500 may have value in the treatment of neuropathic pain.




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L. A. Kobierski, S. Abdi, L. DiLorenzo, N. Feroz, and D. Borsook
A Single Intravenous Injection of KRN5500 (Antibiotic Spicamycin) Produces Long-Term Decreases in Multiple Sensory Hypersensitivities in Neuropathic Pain
Anesth. Analg., July 1, 2003; 97(1): 174 - 182.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2000 by the International Anesthesia Research Society.