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AMBULATORY ANESTHESIA

Postoperative Nausea and Vomiting After Sevoflurane With or Without Ondansetron Compared with Propofol in Female Patients Undergoing Breast Surgery

Ritva M. Jokela, MD^*,, Tuula A. Kangas-Saarela, MD, PhD, Jukka V. I. Valanne, MD, PhD^*, Merja K. Koivuranta, MD, PhD^*, Pirjo O. Ranta, MD, PhD, and Seppo M. Alahuhta, MD, PhD

*Department of Anesthesia, Lapland Central Hospital, Rovaniemi; Department of Anesthesia and Intensive Care, Women’s Hospital, University of Helsinki, Helsinki; and Department of Anesthesia, Oulu University Hospital, Oulu, Finland

Address correspondence and reprint requests to Ritva Jokela, MD, Department of Anesthesia and Intensive Care, Women’s Hospital, University of Helsinki, PO Box 140 (Haartmaninkatu 2), FIN-00029 HUS, Finland. Address e-mail to Ritva.M.Jokela{at}hus.fi

Implications: We studied 180 female patients undergoing breast surgery. The patients were randomly allocated to receive one of three anesthetic techniques. Compared with either propofol or sevoflurane alone, sevoflurane with ondansetron resulted in a decreased incidence of postoperative nausea and vomiting. Sevoflurane with ondansetron prophylaxis is a good alternative to propofol with respect to avoiding postoperative nausea and vomiting.

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