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Anesth Analg 2001;92:344-346
© 2001 International Anesthesia Research Society

CARDIOVASCULAR ANESTHESIA

The Use of Lepirudin for Anticoagulation in Patients with Heparin-Induced Thrombocytopenia During Major Vascular Surgery

Yang Sun, MD, Philip E. Greilich, MD, Steve I. O. Wilson, MD, Mark R. Jackson, MD, and Charles W. Whitten, MD

Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas

Address correspondence and reprint requests to Philip E. Greilich, MD, Anesthesiology and Pain Management Service (112A), Veterans Affairs North Texas Health Care System, 450. 0 South Lancaster Road, Dallas, TX 75216. Address e-mail to philip. greilich{at}email.swmed.edu

IMPLICATIONS: The method of anticoagulation in patients undergoing major vascular surgery with a history of heparin-induced thrombocytopenia (HIT) is controversial. We present two cases in which a bolus only technique using recombinant hirudin (Lepirudin or Refludan) was used successfully in patients with HIT scheduled for vascular surgery.




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K. R. McCrae, J. B. Bussel, P. M. Mannucci, G. Remuzzi, and D. B. Cines
Platelets: An Update on Diagnosis and Management of Thrombocytopenic Disorders
Hematology, January 1, 2001; 2001(1): 282 - 305.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2001 by the International Anesthesia Research Society.