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PEDIATRIC ANESTHESIA

Sonoclot Analysis in Healthy Children

Evan G. Pivalizza, MBChB, FFASA^*, Penelope J. Pivalizza, MD, Spencer Kee, MBChB, FRCA^*, Lewis I. Gottschalk, MBChB, FFASA^*, Peter Szmuk, MD^*, and David C. Abramson, MBChB, FFASA^**

Department of Anesthesiology, *Medical School, and School of Public Health, University of Texas Health Science Center, Houston, Texas

Address correspondence and reprint requests to Evan G. Pivalizza, MBChB, FFASA, Department of Anesthesiology, Medical School, University of Texas Health Science Center, MSB 5.020, 6431 Fannin St., Houston, TX, 77030. Address e-mail to Evan.G.Pivalizza@ uth.tmc.edu.

Although use of the Sonoclot device (Sienco, Inc., Morrison, CO) has been reported in isolated pediatric cases and in small reports in neonates, there are no published data for normal pediatric patients. As the device is used in situations of abnormal coagulation, such as cardiac and liver transplantation surgery, our aim was to determine normal data ranges in healthy pediatric surgical patients. Blood was withdrawn after anesthetic induction, and the Sonoclot activated clotting time, rate of clot formation, time to peak amplitude, and peak amplitude was compared among four pediatric groups (<12 mo, 13–24 mo, 25–48 mo, 49 mo–9 yr) and an adult group. The Sonoclot activated clotting time in the <12-mo and the Adult groups were shorter than the oldest group of children (P < 0.05), although all were within the anticipated normal range, and there were no significant differences in clot rate, peak amplitude, and time to peak amplitude among groups without apparent trends with increasing age. These Sonoclot variables quantify adequate global clot formation in pediatric patients and will facilitate clinical coagulation management with appropriate pediatric normal ranges, avoiding the application of extrapolated adult data to children.

Implications: Sonoclot variables are presented for 95 healthy pediatric surgical patients in four age groups, with small differences found in the Sonoclot (Sienco, Inc., Morrison, CO) activated clotting time between two groups and no significant differences in three other variables among groups.

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				T J Coats, E Brazil, and M Heron The effects of commonly used resuscitation fluids on whole blood coagulation. Emerg. Med. J., July 1, 2006; 23(7): 546 - 549. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999