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Anesth Analg 2001;92:1232-1236
© 2001 International Anesthesia Research Society

CRITICAL CARE AND TRAUMA

Prolonged Sedation with Propofol in the Rat Does Not Result in Sleep Deprivation

Avery Tung, MD*, James P. Lynch, BA*, and Wallace B. Mendelson, MD{dagger}

Departments of *Anesthesia and Critical Care and {dagger}Psychiatry, Physiology, and Medicine, The University of Chicago, Chicago, Illinois

Address correspondence and reprint requests to Avery Tung, MD, Department of Anesthesia and Critical Care, The University of Chicago, 5841 S. Maryland Avenue, MC 4028, Chicago IL 60637. Address e-mail to atung{at}airway.uchicago.edu

The use of propofol provides sedation without prolonging emergence in patients in the Intensive Care Unit. When prolonged, however, continuous sedation may overlap with naturally occurring sleep periods and potentially increase the risk of sleep deprivation. We modified an established rat model of sleep to determine whether prolonged, continuous sedation results in sleep deprivation. Rats were continuously sedated for a 12-h period overlapping completely with their normal sleep phase. Electroencephalogram (EEG) and movement data were collected before and after the sedation period. Rats were evaluated for EEG and movement evidence of sleep deprivation after sedation. When compared with baseline, the time spent in rapid eye movement (REM) and non-REM sleep was decreased during the first 4 h after sedation. The duration of non-REM sleep bouts was not altered. Power in the {delta} band (0.5–4 Hz) during non-REM sleep was diminished during the first 2 h only. Movements were reduced during the first hour after emergence from sedation only. In summary, no EEG or behavioral evidence of sleep deprivation was observed on emergence from sedation. These results imply that sedation is associated with a restorative process reversing the na-tural accumulation of sleep need that occurs during wakefulness.

Implications: Prolonged sedation in the Intensive Care Unit may alter the restorative effects of naturally occurring sleep. We sedated rats during their sleep phase to determine whether sedation interferes with sleep. Upon emergence, no evidence of sleep deprivation was observed. Sedation may thus be associated with a restorative effect similar to sleep.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2001 by the International Anesthesia Research Society.