JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Charuluxananan, S. Articles by Nimcharoendee, K. Search for Related Content PubMed PubMed Citation Articles by Charuluxananan, S. Articles by Nimcharoendee, K.

---

OBSTETRIC ANESTHESIA

Nalbuphine Versus Propofol for Treatment of Intrathecal Morphine-Induced Pruritus After Cesarean Delivery

Department of Anesthesiology, the Clinical Epidemiology Unit, and the Department of Preventive Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Address correspondence and reprint requests to Charuluxananan Somrat, MD, Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand.

In this prospective, randomized, double-blinded study, we compared the efficacy of nalbuphine and propofol for treating intrathecal morphine-induced pruritus after cesarean delivery. One-hundred-eighty-one parturients who developed moderate to severe pruritus after the administration of intrathecal morphine were randomly allocated into two groups. One group received 3 mg IV nalbuphine (n = 91), and the other received 20 mg IV propofol (n = 90). The improvement of pruritus and other adverse effects was determined at 10 min after study drug administration. The treatment success rate was higher in the Nalbuphine group than in the Propofol group (83% vs 61%; P < 0.001). Among the successfully treated patients, recurrence rates of moderate to severe pruritus within 4 h were not significantly different (nalbuphine 9% versus propofol 7%; P = 0.76). Other side effects, such as decreased analgesia, increased nausea, vomiting, increased sedation, pain on injection, and dizziness, were not significantly different between groups. Sedation and pain on injection, which were the two most common side effects, were minor and clinically inconsequential.

Implications: Nalbuphine was superior to propofol for the treatment of intrathecalmorphine-induced pruritus after cesarean delivery.

This article has been cited by other articles:

				C. A. Iatrou, C. K. Dragoumanis, T. D. Vogiatzaki, G. I. Vretzakis, C. E. Simopoulos, and V. K. Dimitriou Prophylactic Intravenous Ondansetron and Dolasetron in Intrathecal Morphine-Induced Pruritus: A Randomized, Double-Blinded, Placebo-Controlled Study Anesth. Analg., November 1, 2005; 101(5): 1516 - 1520. [Abstract] [Full Text] [PDF]

				S. Charuluxananan, O. Kyokong, W. Somboonviboon, A. Narasethakamol, and P. Promlok Nalbuphine Versus Ondansetron for Prevention of Intrathecal Morphine-Induced Pruritus After Cesarean Delivery Anesth. Analg., June 1, 2003; 96(6): 1789 - 1793. [Abstract] [Full Text] [PDF]

				B. Ben-David, P. J. DeMeo, C. Lucyk, and D. Solosko Minidose Lidocaine-Fentanyl Spinal Anesthesia in Ambulatory Surgery: Prophylactic Nalbuphine Versus Nalbuphine Plus Droperidol Anesth. Analg., December 1, 2002; 95(6): 1596 - 1600. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999