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PEDIATRIC ANESTHESIA

The Effect on the Hemodynamic Stability of Varying Calcium Chloride Administration During Protamine Infusion in Pediatric Open-Heart Patients

Vorasri Muangmingsuk, MD^*, Thomas F. Tremback, MD^*, Sunthorn Muangmingsuk, MD^*, David A. Roberson, MD^*, and Nancy E. Cipparrone, MA

*Department of Anesthesia, The Heart Institute for Children, Advocate Christ Hospital and Medical Center; and Department of Research and Education, Advocate Health Care, Oak Lawn, Illinois

Address correspondence and reprint requests to Thomas F. Tremback, MD, Department of Anesthesia, Christ Hospital and Medical Center, 4440 W. 95th St., Oak Lawn, IL 60453.

Implications: We conducted a randomized study in 147 pediatric patients undergoingcardiopulmonary bypass to determine when there are any differences inhemodynamic effects if CaCl₂ 20 mg/kg and protamine 5mg/kg are mixed together and infused over 10 min versus administering half ofthe calcium dose (10 mg/kg) as a bolus followed by a 10-min infusion ofprotamine 5 mg/kg and CaCl₂ 10mg/kg.