An Effective Treatment of Severe Intractable Bleeding After Valve Repair by One Single Dose of Activated Recombinant Factor VII

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Anesth Analg 2001;93:287-289
© 2001 International Anesthesia Research Society

CARDIOVASCULAR ANESTHESIA

An Effective Treatment of Severe Intractable Bleeding After Valve Repair by One Single Dose of Activated Recombinant Factor VII

Herman G. D. Hendriks, MD^*, Joost M. A. A. van der Maaten, MD^*, Joost de Wolf, MD, PhD, Tjalling W. Waterbolk, MD, Maarten J. H. Slooff, MD, PhD, and Jan van der Meer, MD, PhD^||||

Departments of *Anesthesiology, ${dagger}$ Hematology, ${ddagger}$ Thoracic Surgery, $§$ Hepatobiliary Surgery and Liver Transplantation, and the ||||Division of Hemostasis, Thrombosis and Rheology, University Hospital, Groningen, The Netherlands

Address correspondence and reprint requests to H. G. D. Hendriks, MD, Groningen University Hospital, Department of Anesthesiology, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands. Address e-mail to h.g.d.hendriks{at}anest.azg.nl

IMPLICATIONS: The successful treatment with recombinant factorVIIa of a patient experiencing intractable bleeding after cardiacsurgery is described.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598 Print ISSN: 0003-2999

				K. A. Tanaka, T. Taketomi, F. Szlam, A. Calatzis, and J. H. Levy Improved Clot Formation by Combined Administration of Activated Factor VII (NovoSeven(R)) and Fibrinogen (Haemocomplettan(R) P) Anesth. Analg., March 1, 2008; 106(3): 732 - 738. [Abstract] [Full Text] [PDF]

				O. Warren, K. Mandal, V. Hadjianastassiou, L. Knowlton, S. Panesar, K. John, A. Darzi, and T. Athanasiou Recombinant Activated Factor VII in Cardiac Surgery: A Systematic Review Ann. Thorac. Surg., February 1, 2007; 83(2): 707 - 714. [Abstract] [Full Text] [PDF]

				J. Jaggers and J. H. Lawson Coagulopathy and Inflammation in Neonatal Heart Surgery: Mechanisms and Strategies Ann. Thorac. Surg., June 1, 2006; 81(6): S2360 - S2366. [Full Text] [PDF]

				S. Romagnoli, S. Bevilacqua, S. Gelsomino, S. Pradella, L. Ghilli, C. Rostagno, G. F. Gensini, and C. Sorbara Small-Dose Recombinant Activated Factor VII (NovoSeven(R)) in Cardiac Surgery. Anesth. Analg., May 1, 2006; 102(5): 1320 - 1326. [Abstract] [Full Text] [PDF]

				J. H. Levy Overview of clinical efficacy and safety of pharmacologic strategies for blood conservation Am. J. Health Syst. Pharm., September 15, 2005; 62(18_Supplement_4): S15 - S19. [Abstract] [Full Text] [PDF]

				M. Hyllner, E. Houltz, and A. Jeppsson Recombinant activated factor VII in the management of life-threatening bleeding in cardiac surgery Eur. J. Cardiothorac. Surg., August 1, 2005; 28(2): 254 - 258. [Abstract] [Full Text] [PDF]

				P. Raivio, R. Suojaranta-Ylinen, and A. H. Kuitunen Recombinant Factor VIIa in the Treatment of Postoperative Hemorrhage After Cardiac Surgery Ann. Thorac. Surg., July 1, 2005; 80(1): 66 - 71. [Abstract] [Full Text] [PDF]

				R. J. DiDomenico, M. G. Massad, J. Kpodonu, R. A. Navarro, and A. S. Geha Use of Recombinant Activated Factor VII for Bleeding Following Operations Requiring Cardiopulmonary Bypass Chest, May 1, 2005; 127(5): 1828 - 1835. [Abstract] [Full Text] [PDF]

				M. S. Lam and R. P Sims-McCallum Recombinant Factor VIIa in the Treatment of Non-Hemophiliac Bleeding Ann. Pharmacother., May 1, 2005; 39(5): 885 - 891. [Abstract] [Full Text] [PDF]

				A. M. Mahdy and N. R. Webster Perioperative systemic haemostatic agents Br. J. Anaesth., December 1, 2004; 93(6): 842 - 858. [Abstract] [Full Text] [PDF]

				J. D Flynn, M. Pajoumand, P. C Camp Jr, M S. Jahania, C. Ramaiah, and W. S Akers Recombinant Factor VIIa for Refractory Bleeding Following Orthotopic Heart Transplantation Ann. Pharmacother., October 1, 2004; 38(10): 1639 - 1642. [Abstract] [Full Text] [PDF]

				J. D. Tobias, J. M. Simsic, S. Weinstein, W. Schechter, V. Kartha, and R. Michler Recombinant Factor VIIa to Control Excessive Bleeding Following Surgery for Congenital Heart Disease in Pediatric Patients J Intensive Care Med, September 1, 2004; 19(5): 270 - 273. [Abstract] [PDF]

				T. Szabo, S. Ali, and E. M. Camporesi Intraoperative Recombinant Activated Factor VII for Emergent Epidural Hematoma Evacuation Anesth. Analg., August 1, 2004; 99(2): 595 - 597. [Abstract] [Full Text] [PDF]

				D. R. McIlroy and A. J. Silvers Recombinant Factor VIIa for Life-Threatening Bleeding in High-Risk Cardiac Surgery Despite Full-Dose Aprotinin Anesth. Analg., July 1, 2004; 99(1): 27 - 30. [Abstract] [Full Text] [PDF]

				G. Stratmann, A. M. deSilva, E. E. Tseng, J. Hambleton, M. Balea, A. J. Romo, M. J. Mann, N. L. Achorn, W. F. Moskalik, and C. W. Hoopes Reversal of Direct Thrombin Inhibition After Cardiopulmonary Bypass in a Patient with Heparin-Induced Thrombocytopenia Anesth. Analg., June 1, 2004; 98(6): 1635 - 1639. [Abstract] [Full Text] [PDF]

				G. Stratmann, I. A. Russell, and S. H. Merrick Use of recombinant factor VIIa as a rescue treatment for intractable bleeding following repeat aortic arch repair Ann. Thorac. Surg., December 1, 2003; 76(6): 2094 - 2097. [Abstract] [Full Text] [PDF]

				A. L. Mindikoglu, A. Anantharaju, J. Villanueva, N. Shah, and D. H. Van Thiel Pericardiocentesis and Pancreatic Aspiration Needle Biopsy in Coagulopathic and Thrombocytopenic Cirrhotic Patient Chest, March 1, 2003; 123(3): 956 - 958. [Abstract] [Full Text] [PDF]

				M. Kastrup, C. von Heymann, H. Hotz, W. F. Konertz, S. Ziemer, W. J. Kox, and C. Spies Recombinant factor VIIa after aortic valve replacement in a patient with osteogenesis imperfecta Ann. Thorac. Surg., September 1, 2002; 74(3): 910 - 912. [Abstract] [Full Text] [PDF]

				W. Dietrich, M. Spannagl, H. G. D. Hendriks, J. M. A. A. van der Maaten, J. Th. M. de Wolf, and J. van der Meer *Caveat Against the Use of Activated Recombinant Factor VII for Intractable Bleeding in Cardiac Surgery Response** Anesth. Analg., May 1, 2002; 94(5): 1369 - 1371. [Full Text] [PDF]