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PAIN MEDICINE

The Effects of Capsaicin Cream on Prostaglandin-Induced Allodynia

Toshiaki Minami, MD, PhD^*, Shiho Bakoshi, Hiroyuki Nakano, MD, PhD^*, Onori Mine, MD^*, Tadatoshi Muratani, MD^*, Hidemaro Mori, MD, PhD^*, and Seiji Ito, MD, PhD

*Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan; Research and Development, Maruishi Pharmaceutical Co. Ltd., Osaka, Japan; and Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan

Address correspondence and reprint requests to Seiji Ito, MD, PhD, Department of Medical Chemistry, Kansai Medical University, 10-15 Fumizono, Moriguchi 570-8506, Japan. Address e-mail to ito{at}takii.kmu.ac.jp

Although intradermal injection of capsaicin produces acute pain and secondary hyperalgesia, long-term topical application of capsaicin cream has been used as a medication for pain relief in various pain conditions. We previously reported that intrathecal administration of prostaglandin (PG) E₂ and PGF₂ into mice induced touch-evoked pain (allodynia) through capsaicin-sensitive and capsaicin-insensitive afferent fibers, respectively. To clarify the mechanism of an analgesic effect by capsaicin cream, here we applied it to the tail and hind paws of mice and investigated its effects on PGE₂- and PGF₂-induced allodynia. Twenty-four-hour pretreatment of mice with 0.025% or 0.05% capsaicin cream markedly alleviated allodynia induced by PGE₂, but not by PGF₂. These results suggest that the topical application of capsaicin cream modulates capsaicin-sensitive afferents and ameliorates allodynia evoked by PGE₂ at the spinal level.

IMPLICATIONS: Topical application of capsaicin cream alleviates touch-evoked pain induced by the intrathecal administration of prostaglandin E₂. This study may provide a rationale for the use of capsaicin cream as a therapeutic drug for pain relief.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999