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ANESTHETIC PHARMACOLOGY

A Comparison of Atenolol, Labetalol, Esmolol, and Landiolol for Altering Human Neutrophil Functions

Kahoru Nishina, MD^*, Hirohiko Akamatsu, MD, Katsuya Mikawa, MD^*, Makoto Shiga, MD^*, Hidefumi Obara, MD^*, and Yukie Niwa, MD

*Department of Anesthesiology and Intensive Care Unit, Kobe University School of Medicine, Kobe, Japan; Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan; and Niwa Institute for Immunology, Kochi, Japan

Address correspondence and reprint requests to Dr. K. Mikawa, Department of Anesthesiology, Kobe University School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe 650-0017, Japan.

IMPLICATIONS: Neutrophils play a pivotal role in the antibacterial host defense system. Atenolol, labetalol, esmolol, and landiolol at clinically relevant concentrations failed to change neutrophil functions. Our findings indicate that we may be able to use these ß-antagonists without great caution in clinical settings.