JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (54) Citing Articles via Google Scholar Google Scholar Articles by Desjardins, P. J. Articles by Hubbard, R. C. Search for Related Content PubMed PubMed Citation Articles by Desjardins, P. J. Articles by Hubbard, R. C. Related Collections Pain Pharmacology

---

PAIN MEDICINE

The Injectable Cyclooxygenase-2-Specific Inhibitor Parecoxib Sodium Has Analgesic Efficacy When Administered Preoperatively

Paul J. Desjardins, DMD, PhD^*, Evie H. Grossman, BS, Michael E. Kuss, BS, Sheela Talwalker, PhD, Shobha Dhadda, PhD, Douglas Baum, BS^*, and Richard C. Hubbard, MD

*Scirex Corporation, Austin, Texas; and Department of Clinical Research, GD Searle, Division of Pharmacia, Skokie, Illinois

Address correspondence and reprint requests to Richard C. Hubbard, Department of Clinical Research, Pharmacia, 4901 Searle Pkwy-A3W, Skokie, IL 60077. Address e-mail to Richard.C. Hubbard{at}pharmacia.com

Preoperative administration of analgesics may prevent or reduce hyperalgesia and inhibit inflammation and pain by reducing the synthesis of prostaglandins in response to surgical injury. We evaluated in this placebo-controlled study the analgesic efficacy and safety of single doses of parecoxib sodium (20, 40, and 80 mg IV) when administered before oral surgery. Efficacy assessments were recorded during the 24-h period after completion of surgery. All doses of parecoxib sodium were consistently and significantly superior to placebo as measured by time to rescue medication, proportion of patients requiring rescue medication, patient’s global assessment, and pain intensity. There were no significant differences between the Parecoxib Sodium 40- and 80-mg groups, suggesting that the analgesic effect of preoperatively administered parecoxib sodium reaches a plateau at 40 mg in this model. Forty-eight percent of the Parecoxib Sodium 40-mg group required rescue medication in the 24-h study period, compared with 93% of patients in the Placebo group. Overall, there were fewer adverse events in parecoxib sodium-treated patients compared with placebo. These findings suggest that preoperative administration of parecoxib sodium, the injectable prodrug of the cyclooxygenase-2 specific inhibitor valdecoxib, is effective, safe, and well tolerated for treating postoperative pain.

IMPLICATIONS: Preoperatively administered antiinflammatory analgesics should theoretically prevent the upregulation of nociception and inhibit inflammation and pain by reducing the synthesis of prostaglandins in response to surgery. The findings of this study demonstrate that preoperative administration of parecoxib sodium is both safe and effective for the treatment of pain after oral surgery.

This article has been cited by other articles:

				S. Niruthisard, T. Werawataganon, P. Bunburaphong, M. Ussawanophakiat, C. Wongsakornchaikul, and K. Toleb Improving the Analgesic Efficacy of Intrathecal Morphine with Parecoxib After Total Abdominal Hysterectomy Anesth. Analg., September 1, 2007; 105(3): 822 - 824. [Abstract] [Full Text] [PDF]

				V. Martinez, A. Belbachir, A. Jaber, K. Cherif, A. Jamal, Y. Ozier, D. I. Sessler, M. Chauvin, and D. Fletcher The Influence of Timing of Administration on the Analgesic Efficacy of Parecoxib in Orthopedic Surgery Anesth. Analg., June 1, 2007; 104(6): 1521 - 1527. [Abstract] [Full Text] [PDF]

				B. Carvalho, L. Chu, A. Fuller, S. E. Cohen, and E. T. Riley Valdecoxib for postoperative pain management after cesarean delivery: a randomized, double-blind, placebo-controlled study. Anesth. Analg., September 1, 2006; 103(3): 664 - 670. [Abstract] [Full Text] [PDF]

				L. Romundstad, H. Breivik, H. Roald, K. Skolleborg, T. Haugen, J. Narum, and A. Stubhaug Methylprednisolone Reduces Pain, Emesis, and Fatigue After Breast Augmentation Surgery: A Single-Dose, Randomized, Parallel-Group Study with Methylprednisolone 125 mg, Parecoxib 40 mg, and Placebo Anesth. Analg., February 1, 2006; 102(2): 418 - 425. [Abstract] [Full Text] [PDF]

				P. F. White Safety of Cox-2 Selective Nonsteroidal Antiinflammatory Drugs for Postsurgical Pain Anesth. Analg., February 1, 2006; 102(2): 646 - 646. [Full Text] [PDF]

				P. F. White The Changing Role of Non-Opioid Analgesic Techniques in the Management of Postoperative Pain Anesth. Analg., November 1, 2005; 101(5S_Suppl): S5 - 22. [Abstract] [Full Text] [PDF]

				P. F. White Changing Role of COX-2 Inhibitors in the Perioperative Period: Is Parecoxib Really the Answer? Anesth. Analg., May 1, 2005; 100(5): 1306 - 1308. [Full Text] [PDF]

				D.R. MEHLISCH, P.J. DESJARDINS, S. DANIELS, and R.C. HUBBARD The analgesic efficacy of intramuscular parecoxib sodium in postoperative dental pain J Am Dent Assoc, November 1, 2004; 135(11): 1578 - 1590. [Abstract] [Full Text] [PDF]

				P. Kranke, A. M. Morin, N. Roewer, and L. H. Eberhart Patients' Global Evaluation of Analgesia and Safety of Injected Parecoxib for Postoperative Pain: A Quantitative Systematic Review Anesth. Analg., September 1, 2004; 99(3): 797 - 806. [Abstract] [Full Text] [PDF]

				P. J. Desjardins, L. Traylor, and R. C. Hubbard Analgesic Efficacy of Preoperative Parecoxib Sodium in an Orthopedic Pain Model J Am Podiatr Med Assoc, May 1, 2004; 94(3): 305 - 314. [Abstract] [Full Text] [PDF]

				G. P. Joshi, E. R. Viscusi, T. J. Gan, H. Minkowitz, M. Cippolle, R. Schuller, R. Y. Cheung, and J. G. Fort Effective Treatment of Laparoscopic Cholecystectomy Pain with Intravenous Followed by Oral COX-2 Specific Inhibitor Anesth. Analg., February 1, 2004; 98(2): 336 - 342. [Abstract] [Full Text] [PDF]

				P. C. Walker and D. S. Wagner Treatment of Pain in Pediatric Patients Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275. [Abstract] [PDF]

				H. S. Smith and W. Baird Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population American Journal of Hospice and Palliative Medicine, July 1, 2003; 20(4): 297 - 306. [Abstract] [PDF]

				T. P. Connolly Cyclooxygenase-2 Inhibitors in Gynecologic Practice Clin. Med. Res., April 1, 2003; 1(2): 105 - 110. [Abstract] [Full Text] [PDF]

				R. C. Hubbard, T. M. Naumann, L. Traylor, and S. Dhadda Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia Br. J. Anaesth., February 1, 2003; 90(2): 166 - 172. [Abstract] [Full Text] [PDF]

				S. Moiniche, J. Romsing, J. B. Dahl, and M. R. Tramer Nonsteroidal Antiinflammatory Drugs and the Risk of Operative Site Bleeding After Tonsillectomy: A Quantitative Systematic Review Anesth. Analg., January 1, 2003; 96(1): 68 - 77. [Abstract] [Full Text] [PDF]

				P. F. White The Role of Non-Opioid Analgesic Techniques in the Management of Pain After Ambulatory Surgery Anesth. Analg., March 1, 2002; 94(3): 577 - 585. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999