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REGIONAL ANESTHESIA

What Constitutes an Effective but Safe Initial Dose of Lidocaine to Test a Thoracic Epidural Catheter?

Stephen J. Holman, MD^*, Richard R. Bosco, MD^*, Tzu-Cheg Kao, PhD, Michael A. Mazzilli, MD, Keith J. Dietrich, MD, Rick A. Rolain, MD, and Rom A. Stevens, MD^*

Departments of *Anesthesiology and Preventive Medicine & Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Anesthesiology, National Naval Medical Center, Bethesda, Maryland; and Department of Anesthesiology, Portsmouth Naval Medical Center, Portsmouth, Virginia

Address correspondence to Dr. Stephen J. Holman, Department of Anesthesiology, USUHS, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799. Address e-mail to sholman{at}usuhs.mil

To investigate the effects of age and dose on the spread of thoracic epidural anesthesia, we placed thoracic epidural catheters in 50 surgical patients divided into groups by age (Group I [young], 18–51 yr; Group II [old], 56–80 yr) and randomly assigned patients to receive either 5 mL (A) or 9 mL (B) of 2% lidocaine (plain) injected via the epidural catheter. Hemodynamic variables were measured (heart rate, mean arterial blood pressure, noninvasive impedance cardiac index) at baseline and every 5 min for 30 min. Detectable blockade occurred within 8 min after injection of 3 + 2 mL or 3 + 6 mL in 48 of 50 patients. Maximum spread of analgesia to pinprick occurred 15–23 min after completion of local anesthetic injection and was significantly different between age and volume groups by two-way analysis of variance (Group IA [young 5], 10.9 ± 4.0 dermatomes; Group IIB [young 9], 13.9 ± 4.5 dermatomes; Group IIA [old 5], 14.1 ± 5.6 dermatomes; and Group IIB [old 9], 17.4 ± 5.1dermatomes). Minor decreases in mean arterial blood pressure (8%–17%) and heart rate (4%–11%) were noted. Two patients in the Old 9 group required IV ephedrine or ephedrine/atropine to treat hypotension and bradycardia. We conclude that given the rapid onset (3–8 min), extensive spread (11–14 dermatomal segments), and consistent hemodynamic stability, thoracic epidural anesthesia should be initiated with lidocaine 100 mg (5 mL 2% lidocaine) to establish proper location of the catheter in the epidural space in both younger and older patients.

IMPLICATIONS: In young and old patients, we evaluated the cardiovascular effects and spread of numbness achieved from injection of local anesthetic (lidocaine 100–180 mg) into the thoracic epidural space and concluded that the smaller dose was quite effective and possibly safer, particularly in older patients.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999