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Anesth Analg 2001;93:1032-1034
© 2001 International Anesthesia Research Society

PAIN MEDICINE

The Long-Term Antinociceptive Effect of Intrathecal S(+)-Ketamine in a Patient with Established Morphine Tolerance

Sabine Sator-Katzenschlager, MD, Engelbert Deusch, MD, Petra Maier, MD, Anna Spacek, MD, and Hans G. Kress, MD PhD

Department of Anesthesiology and Intensive Care B, University of Vienna, Vienna, Austria

Address correspondence to Sabine Sator-Katzenschlager, MD, Department of Anesthesiology and Intensive Care B, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Address e-mail to sabine.sator{at}univie.ac.at

IMPLICATIONS: Our report describes for the first time the continuous long-term intrathecal application of S(+)-ketamine in a patient with chronic pain and morphine tolerance. Intrathecally applied S(+)-ketamine led to a significant pain reduction and consecutively reduced the doses of intrathecal morphine required for pain relief even several weeks after the cessation of the 24-day period of intrathecal S(+)-ketamine administration.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2001 by the International Anesthesia Research Society.