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Anesth Analg 2001;93:1307-1309
© 2001 International Anesthesia Research Society

REGIONAL ANESTHESIA

Systemic Tizanidine Hydrochloride (ZanaflexTM) Partially Decreases Experimental Postoperative Pain in Rats

Allen H. Hord, MD, Donald D. Denson, PhD, and M. Isabel Azevedo, MD

Division of Pain Medicine, Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia

Address correspondence and reprint requests to Allen H. Hord, MD, Department of Anesthesiology, Emory University School of Medicine, 1364 Clifton Rd., NE, Atlanta, GA 30322.

IMPLICATIONS: Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2001 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2001 by the International Anesthesia Research Society.