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Anesth Analg 2002;94:157-162
© 2002 International Anesthesia Research Society

CRITICAL CARE AND TRAUMA

Physiologic Characteristics of Cold Perfluorocarbon-Induced Hypothermia During Partial Liquid Ventilation in Normal Rabbits

Sang-Bum Hong, MD, Younsuck Koh, MD, Tae-Sun Shim, MD, Sang D. Lee, MD, Woo S. Kim, MD, Dong S. Kim, MD, Won D. Kim, MD, and Chae-Man Lim, MD

Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Address correspondence and reprint requests to Chae-Man Lim, MD, Asan Medical Center, Songpa POB 145, Seoul, Korea, 138-600. Address e-mail to cmlim{at}www.amc.seoul.kr

Because perfluorocarbon (PFC) liquid contacts closely with the alveolar capillaries during partial liquid ventilation (PLV), PLV with cold PFC may be used for the induction of hypothermia. Twenty rabbits were randomized to PFC-induced hypothermia (PH) (n = 7; core temperature 35° ± 1°C), surface hypothermia (SH) (n = 7; 35° ± 1°C), or normothermia (n = 6; 39° ± 1°C). We induced PH by repeated in situ exchanges of 0°C perfluorodecalin during PLV. At the establishment (0 min) of hypothermia in the PH group, oxygen consumption (P = 0.04) and oxygen extraction ratio (P = 0.01) decreased from normothermic condition. Metabolic (oxygen consumption, oxygen extraction ratio, serum lactate level) and hemodynamic variables (heart rate, blood pressure, cardiac output, pulmonary artery pressure) of the PH group were not different from those of the SH group at 0, 30, 60, 90, and 120 min of hypothermia. The difference in temperature between the pulmonary artery and rectum during the hypothermic period was smaller in the PH group compared with the SH group (P = 0.033). In conclusion, hypothermia may be induced during PLV by using cold PFC. This "pulmonary method" of cooling was comparable to a systemic method of cooling with regard to a few important physiologic variables, while maintaining a narrower interorgan temperature difference.

IMPLICATIONS: The induction of moderate hypothermia was feasible in rabbits by administrating cold perfluorocarbon liquid into the lung. Physiologic changes induced by this pulmonary cooling were comparable to those induced by systemic cooling. Our method may be regarded as a methodological advance in the field of therapeutic hypothermia.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.