JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dsida, R. M.
Right arrow Articles by Avram, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dsida, R. M.
Right arrow Articles by Avram, M. J.
Related Collections
Right arrow Pediatrics
Right arrow Pain
Anesth Analg 2002;94:266-270
© 2002 International Anesthesia Research Society

PEDIATRIC ANESTHESIA

Age-Stratified Pharmacokinetics of Ketorolac Tromethamine in Pediatric Surgical Patients

Richard M. Dsida, MD*{dagger}, Melissa Wheeler, MD*{dagger}, Patrick K. Birmingham, MD*{dagger}, Zhao Wang, MD{dagger}, Corri L. Heffner, RN*, Charles J. Coté, MD*{dagger}, and Michael J. Avram, PhD{dagger}

*Department of Pediatric Anesthesiology, Children’s Memorial Hospital, Chicago, Illinois; and {dagger}Department of Anesthesiology, Northwestern University Medical School, Chicago, Illinois

Address correspondence and reprint requests to Richard M. Dsida, MD, Department of Pediatric Anesthesiology, Children’s Memorial Hospital, 2300 Children’s Plaza, Chicago, IL 60614. Address e-mail to r-dsida{at}northwestern.edu

Published data suggest that ketorolac pharmacokinetics are different in children than in adults. We sought to better characterize ketorolac pharmacokinetics in children. Thirty-six children, aged 1–16 yr, were stratified into four age groups: 1–3 yr, 4–7 yr, 8–11 yr, and 12–16 yr. Each child received 0.5 mg/kg of ketorolac tromethamine IV after completion of elective surgery. A maximum of 16 venous blood samples (mean, 13 ± 2) were collected at predetermined times up to 10 h after drug administration. Plasma ketorolac concentrations were measured by high-performance liquid chromatography after solid-phase extraction. Individual concentration-versus-time relationships were best fit to a two-compartment pharmacokinetic model by using SAAM II. Body weight-normalized pharmacokinetic variables did not differ among the age groups and were similar to those reported for adults, including a volume of distribution at steady state of 113 ± 33 mL/kg (mean ± SD) and an elimination clearance of 0.57 ± 0.17 mL · min-1 · kg-1. Our study demonstrates that a single dose of ketorolac (0.5 mg/kg) results in plasma concentrations in the adult therapeutic concentration range for 6 h in most children. Our data provide no evidence that children require either larger weight-adjusted doses or shorter dosing intervals than adults to provide similar plasma drug concentrations.

IMPLICATIONS: The literature suggests that ketorolac disposition differs between children and adults. We characterized ketorolac pharmacokinetics in 36 children. Body weight-normalized two-compartment pharmacokinetic variables did not differ among pediatric patients <17 yr old and were similar to adult values.




This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
E. Kumpulainen, H. Kokki, M. Laisalmi, M. Heikkinen, J. Savolainen, J. Rautio, and M. Lehtonen
How Readily Does Ketorolac Penetrate Cerebrospinal Fluid in Children?
J. Clin. Pharmacol., April 1, 2008; 48(4): 495 - 501.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
A. Jeyakumar, T. M. Brickman, M. E. Williamson, K. Hirose, P. Krakovitz, K. Whittemore, and C. Discolo
Nonsteroidal Anti-inflammatory Drugs and Postoperative Bleeding Following Adenotonsillectomy in Pediatric Patients
Arch Otolaryngol Head Neck Surg, January 1, 2008; 134(1): 24 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. M. Lynn, H. Bradford, E. D. Kantor, K.-Y. Seng, D. H. Salinger, J. Chen, R. G. Ellenbogen, P. Vicini, and G. D. Anderson
Postoperative Ketorolac Tromethamine Use in Infants Aged 6-18 Months: The Effect on Morphine Usage, Safety Assessment, and Stereo-Specific Pharmacokinetics
Anesth. Analg., May 1, 2007; 104(5): 1040 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. Hackmann
Smaller Dose of 0.5 mg/kg IV Ketorolac Is Sufficient to Provide Pain Relief in Children
Anesth. Analg., January 1, 2004; 98(1): 275 - 276.
[Full Text] [PDF]

Home page
 JWatch Emergency Med.Home page
Ketorolac Pharmacokinetics Don't Differ in Children and Adults
Journal Watch Emergency Medicine, April 17, 2002; 2002(417): 9 - 9.
[Full Text]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.