This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Volmanen, P. Articles by Alahuhta, S. Search for Related Content PubMed PubMed Citation Articles by Volmanen, P. Articles by Alahuhta, S. Related Collections Obstetrics Pharmacology

---

OBSTETRIC ANESTHESIA

Remifentanil in Obstetric Analgesia: A Dose-Finding Study

Petri Volmanen, MD^*, Ethem I. Akural, MD, Tytti Raudaskoski, MD, PhD, and Seppo Alahuhta, MD, PhD

*Lapland Central Hospital, Rovaniemi, Finland; and Departments of Anaesthesiology and Obstetrics and Gynaecology, University of Oulu, Oulu, Finland

Address correspondence and reprint requests to Petri Volmanen, MD, Lapland Central Hospital, PL 8041, 96101 Rovaniemi, Finland. Address e-mail to petri.volmanen{at}lshp.fi

IV patient-controlled analgesia (PCA) with remifentanil is a new approach in systemic opioid analgesia during labor. We determined the minimum effective dose of IV remifentanil by increasing the PCA bolus from 0.2 µg/kg with 0.2 µg/kg increments during a 60-min study period until the analgesia was considered adequate by the parturient. Twenty healthy parturients with singleton pregnancies participated in the study during the first stage of labor. Remifentanil hydrochloride was given IV via PCA over 1 min with a lockout time of 1 min. The parturient started the PCA bolus at the first subjective sign of uterine contraction. All 17 patients who completed the study reached adequate pain relief. The median effective PCA bolus was 0.4 µg/kg and consumption was 0.066 µg · kg^-1 · min^-1, with wide individual variation (0.2–0.8 µg/kg and 0.027–0.207 µg · kg^-1 · min^-1, respectively). The pain scores were reduced by a median of 4.2 (25th–75th percentiles, 3.1–5.2; P < 0.001) on an 11-point numeric scale. Although there was a wide individual variation in the dose required, remifentanil seems effective for labor analgesia. However, maternal oxygen desaturation, sedation, and reduced fetal heart rate beat-to-beat variability were observed frequently. There was wide individual variation in the dose required for effective labor analgesia. Potentially serious side effects, which were observed frequently during remifentanil analgesia, may limit remifentanil’s use in obstetrics.

IMPLICATIONS: We determined the minimum effective dose of patient-controlled IV remifentanil for labor analgesia. There was wide individual variation in the dose required for effective labor analgesia. Potentially serious side effects, which were observed frequently during remifentanil analgesia, may limit its use in obstetrics.

This article has been cited by other articles:

				B. Singler, A. Troster, N. Manering, J. Schuttler, and W. Koppert Modulation of Remifentanil-Induced Postinfusion Hyperalgesia by Propofol Anesth. Analg., June 1, 2007; 104(6): 1397 - 1403. [Abstract] [Full Text] [PDF]

				A. Butwick and B. Carvalho Remifentanil Patient-Controlled Analgesia in Labor Anesth. Analg., January 1, 2006; 102(1): 333 - 333. [Full Text] [PDF]

				I. Volikas, A. Butwick, C. Wilkinson, A. Pleming, and G. Nicholson Maternal and neonatal side-effects of remifentanil patient-controlled analgesia in labour Br. J. Anaesth., October 1, 2005; 95(4): 504 - 509. [Abstract] [Full Text] [PDF]

				M. Van de Velde, D. Van Schoubroeck, L. E. Lewi, M. A.E. Marcus, J. C. Jani, C. Missant, A. Teunkens, and J. A. Deprest Remifentanil for Fetal Immobilization and Maternal Sedation During Fetoscopic Surgery: A Randomized, Double-Blind Comparison with Diazepam Anesth. Analg., July 1, 2005; 101(1): 251 - 258. [Abstract] [Full Text] [PDF]

				J. R. Sneyd Recent advances in intravenous anaesthesia Br. J. Anaesth., November 1, 2004; 93(5): 725 - 736. [Abstract] [Full Text] [PDF]

				T. D. Egan, S. E. Kern, K. T. Muir, and J. White Remifentanil by bolus injection: a safety, pharmacokinetic, pharmacodynamic, and age effect investigation in human volunteers{dagger} Br. J. Anaesth., March 1, 2004; 92(3): 335 - 343. [Abstract] [Full Text] [PDF]

				T. A. Saunders and P. S.A. Glass A Trial of Labor For Remifentanil Anesth. Analg., April 1, 2002; 94(4): 771 - 773. [Full Text] [PDF]