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ANESTHETIC PHARMACOLOGY

Dystonic Reaction to Propofol Attenuated by Benztropine (Cogentin)

Department of Anaesthesia, Sunnybrook & Women’s College Health Sciences Centre, University of Toronto, Canada

Address correspondence and reprint requests to Beverley Orser, MD, PhD, Department of Anaesthesia, Sunnybrook & Women’s College Health Sciences Centre, University of Toronto, 2075 Bayview Ave., Toronto, Ontario, M4N 3M5, Canada. Address e-mail to beverley.orser{at}utoronto.ca

IMPLICATIONS: Neuroexcitatory movements associated with propofol anesthesia are well recognized. Here we report on the successful use of benztropine (2 mg) to abolish abnormal dystonic movements after propofol anesthesia. Forty-five case reports are reviewed, and a treatment strategy for abnormal movements during propofol anesthesia is provided.

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Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999