This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Nishihara, F. Articles by Saito, S. Search for Related Content PubMed PubMed Citation Articles by Nishihara, F. Articles by Saito, S.

---

TECHNOLOGY, COMPUTING, AND SIMULATION

Pre-Ictal Bispectral Index Has a Positive Correlation with Seizure Duration During Electroconvulsive Therapy

Department of Anesthesiology & Reanimatology, Gunma University School of Medicine, Maebashi, Japan

Address correspondence and reprint requests to Shigeru Saito, MD, Department of Anesthesiology & Reanimatology, Gunma University School of Medicine, 3-39-22, Showamachi, Maebashi, 371-8511, Japan. Address e-mail to shigerus{at}news.sb.gunma-u.ac.jp

Propofol anesthesia increases the seizure threshold of patients receiving electroconvulsive therapy. Excessive neuronal suppression could result in an unacceptably short seizure. We sought to identify the correlation between the pre-ictal bispectral index (BIS) score and seizure duration in patients receiving electroconvulsive therapy under propofol anesthesia. BIS was monitored in 38 psychotically depressed patients. Anesthesia was induced by a bolus injection of 1 mg/kg of propofol. The duration of muscular and electroencephalographic seizure was measured during the therapy. The BIS immediately before the electrical shock was 54 ± 13. Both muscular and electroencephalographic seizure durations had a positive correlation with pre-ictal BIS (r = 0.68 and 0.73, respectively; P < 0.01). After the electrically induced seizure, BIS decreased to 30 ± 8, reflecting post-ictal suppression. BIS scores when the patients had awakened after the seizure had a wide variation (range, 29–81; mean, 45; SD, 13). In conclusion, seizure duration has a positive correlation with BIS immediately before electrical shock; however, BIS may not be an accurate predictor of awakening after electrical shock.

IMPLICATIONS: Pre-ictal bispectral index had a positive correlation with seizure duration and could be useful to prevent an unacceptably short seizure in electroconvulsive therapy under propofol anesthesia.

This article has been cited by other articles:

				B. Donnelly and V. Boyd Use of the bispectral index (BIS) monitor to aid in the diagnosis of pseudoseizures. Br. J. Anaesth., April 1, 2006; 96(4): 538 - 539. [Full Text] [PDF]

				A. A. Dahaba Different Conditions That Could Result in the Bispectral Index Indicating an Incorrect Hypnotic State Anesth. Analg., September 1, 2005; 101(3): 765 - 773. [Abstract] [Full Text] [PDF]

				R. Ochiai, T. Yamada, S. Kiyama, T. Nakaoji, and J. Takeda Bispectral Index as an Indicator of Seizure Inducibility in Electroconvulsive Therapy Under Thiopental Anesthesia Anesth. Analg., April 1, 2004; 98(4): 1030 - 1035. [Abstract] [Full Text] [PDF]

				P. F. White, S. Rawal, A. Recart, L. Thornton, M. Litle, and L. Stool Can the Bispectral Index Be Used to Predict Seizure Time and Awakening After Electroconvulsive Therapy? Anesth. Analg., June 1, 2003; 96(6): 1636 - 1639. [Abstract] [Full Text] [PDF]