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Anesth Analg 2002;94:1312-1314
© 2002 International Anesthesia Research Society

OBSTETRIC ANESTHESIA

The Influences of Maternal Albumin Concentrations on the Placental Transfer of Propofol in Human Dually Perfused Cotyledon In Vitro

Yan-Ling He, PhD, Hiroshi Seno, MD, Ken Sasaki, MD, and Chikara Tashiro, MD

Department of Anesthesiology, Hyogo College of Medicine, Nishinomiya City, Japan

Address correspondence and reprint requests to Yan-Ling He, PhD, Department of Anesthesiology, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya City 663-8501, Japan. Address e-mail to Yhe{at}partners.org

IMPLICATIONS: These results indicate that fetal exposure to propofol can vary considerably depending on maternal plasma albumin concentration. A fractional change in the maternal protein binding of propofol can result in a relatively large difference in fetal exposure.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2002 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.