| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
*
lu*
Departments of *Anaesthesiology and Biostatistics, Trakya University, Edirne, Turkey
Address correspondence and reprint requests to Dr. Dilek Memi, Trakya University Medical Faculty, Department of Anaesthesiology and Reanimation, 22030, Edirne, Turkey. Address e-mail to dilmemis{at}mynet.com
We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing pain caused by the injection of rocuronium in 250 patients. After tourniquet application on the forearm, the patients were given saline (3 mL) (Group 1, n = 50), ondansetron (4 mg) (Group 2, n = 50), lidocaine (30 mg) (Group 3, n = 50), tramadol (50 mg) (Group 4, n = 50), or fentanyl (100 µg) (Group 5, n = 50) diluted into a 3-mL solution. The occlusion was released after 20 s and rocuronium was injected over 10–15 s. The patients were observed and asked immediately if they had pain in the arm, and the response was assessed. Reactions such as discomfort and pain, withdrawal of the hand, and so on after the administration of rocuronium were recorded as side effects for 24 h. Ten patients in Group 1, 28 patients in Group 2, 37 patients in Group 3, 30 patients in Group 4, and 15 patients in Group 5 reported no pain. Light pain was seen in 11 patients in Group 1, 14 patients in Group 2, 11 patients in Group 3, 12 patients in Group 4, and 20 patients in Group 5. Moderate pain was seen in 15 patients in Group 1, 6 patients in Group 2, 2 patients in Group 3, 8 patients in Group 4, and 10 patients in Group 5. Severe pain was seen in 14 patients in Group 1, 2 patients in Group 2, 0 patients in Group 3, 0 patients in Group 4, and 5 patients in Group 5. Correlation determined with log-linear analysis found in Group 1 pain score 0 (P < 0.001), Group 1 pain score 1 (P < 0.001), and Group 3 pain score 0 (P < 0.001). We conclude that ondansetron, lidocaine, tramadol, and fentanyl decrease the level of rocuronium injection pain. Among these drugs, lidocaine is the most effective, whereas fentanyl is the least effective.
IMPLICATIONS: We compared the efficacy of ondansetron, lidocaine, tramadol, and fentanyl in minimizing the pain on injection of rocuronium in 250 patients. Ondansetron, lidocaine, tramadol, and fentanyl were effective in preventing and decreasing the level of rocuronium injection pain. Among these drugs, lidocaine was the most effective, and fentanyl was the least effective.
This article has been cited by other articles:
|
|
 |
|
  J. Y. Kim, J. Y. Kim, Y. B. Kim, and H. J. Kwak Pretreatment with remifentanil to prevent withdrawal after rocuronium in children Br. J. Anaesth., January 1, 2007; 98(1): 120 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ahmad, C. Y. Choy, E. A. Aris, and S. Balan Preventing the Withdrawal Response Associated with Rocuronium Injection: A Comparison of Fentanyl with Lidocaine Anesth. Analg., April 1, 2005; 100(4): 987 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tuncali, A. Karci, B. E. Tuncali, O. Mavioglu, C. G. Olguner, S. Ayhan, and Z. Elar Dilution of Rocuronium to 0.5 mg/mL with 0.9% NaCl Eliminates the Pain During Intravenous Injection in Awake Patients Anesth. Analg., September 1, 2004; 99(3): 740 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-T. Liou, J.-C. Hsu, F.-C. Liu, D. Ching-Wah Sum, and P.-W. Lui Pretreatment with Small-Dose Ketamine Reduces Withdrawal Movements Associated with Injection of Rocuronium in Pediatric Patients Anesth. Analg., November 1, 2003; 97(5): 1294 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
