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Anesth Analg 2002;94:1583-1585
© 2002 International Anesthesia Research Society

CRITICAL CARE AND TRAUMA

Propylene Glycol Toxicity Associated with Lorazepam Infusion in a Patient Receiving Continuous Veno-Venous Hemofiltration with Dialysis

Ali H. Al-Khafaji, MD, William E. Dewhirst, MD, and Harold L. Manning, MD FCCP

Section of Critical Care Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Address correspondence and reprint requests to Ali H. Al-Khafaji, MD, Section of Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. Address e-mail to Ali.H.Al-Khafaji{at}Hitchcock.org

IMPLICATIONS: We report a case of toxicity from the drug solvent propylene glycol resulting from prolonged, large-dose lorazepam infusion. The case is unusual in that toxicity developed during continuous veno-venous hemofiltration with dialysis, a renal replacement therapy that should been have been effective at eliminating the chemical and its metabolites.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.