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Anesth Analg 2002;94:1617-1620
© 2002 International Anesthesia Research Society

REGIONAL ANESTHESIA

Small-Dose Propofol Sedation Attenuates the Formation of Reactive Oxygen Species in Tourniquet-Induced Ischemia-Reperfusion Injury Under Spinal Anesthesia

Ya-Jung Cheng, MD*, Yong-Ping Wang, MD*, Chiang-Ting Chien, PhD{dagger}, and Chau-Fong Chen, PhD{ddagger}

*Department of Anesthesiology and {dagger}Office for Medical Research Administration, National Taiwan University Hospital, and {ddagger}Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan

Address correspondence and reprint request to Chau-Fong Chen, PhD, Department of Physiology, College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei, Taiwan 10016, Republic of China. Address e-mail to chfochen{at}ha.mc ntu.edu.tw.

The release of a tourniquet produces reactive oxygen species (ROS), which can cause ischemia-reperfusion injury. We investigated the effects on ROS production in 22 adult ASA physical status I–II patients sedated with small-dose propofol infusion and IV midazolam undergoing elective total knee replacement under intrathecal anesthesia, allocated randomly to one of two groups. In the Propofol group, sedation was performed with propofol 0.2 mg/kg followed by infusion at a rate of 2 mg · kg-1 · h-1. In the Control group, IV midazolam 5 mg was given. ROS production was measured by lucigenin chemiluminescence analysis. Blood samples were obtained from the radial artery after spinal anesthesia, 1 min before release of the tourniquet and 5 and 20 min after reperfusion. The ischemic time was approximately 70 min. ROS production decreased nonsignificantly before reperfusion in both groups but increased significantly 5 and 20 min after reperfusion in the Midazolam group. In the Propofol group, no significant increase of ROS production was found. We conclude that small-dose propofol infusion attenuates ROS production in tourniquet-induced ischemia-reperfusion injury.

IMPLICATIONS: Small-dose propofol sedation, compared with IV midazolam, attenuates free radical production after release of the tourniquet during total knee replacement under spinal anesthesia.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.