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Anesth Analg 2002;95:144-147
© 2002 International Anesthesia Research Society

ANESTHETIC PHARMACOLOGY

The Efficacy of Lafutidine in Improving Preoperative Gastric Fluid Property: A Comparison with Ranitidine and Rabeprazole

Takanobu Uesugi, MD, Katsuya Mikawa, MD, Kahoru Nishina, MD, Osamu Morikawa, MD, Yumiko Takao, MD, and Hidefumi Obara, MD

Department of Anesthesia and Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kobe, Japan

Address correspondence and reprint requests to Dr. K. Mikawa, Department of Anesthesia and Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe 650-0017, Japan. Address e-mail to katz{at}post.med.kobe-u.ac.jp

IMPLICATIONS: Acid aspiration syndrome remains a potentially critical perioperative complication. We compared lafutidine, ranitidine, and rabeprazole for reduction of preoperative gastric fluid acidity and volume in elective surgery and found that these variables were minimized with a single morning dose of lafutidine 20 mg compared with ranitidine or rabeprazole. Preoperative oral lafutidine may be an alternative to ranitidine as a prophylaxis against aspiration pneumonia.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.