This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Vivien, B. Articles by Riou, B. Search for Related Content PubMed PubMed Citation Articles by Vivien, B. Articles by Riou, B. Related Collections Cardiovascular Pharmacology

---

CARDIOVASCULAR ANESTHESIA

The Paradoxical Positive Inotropic Effect of Sevoflurane in Healthy and Cardiomyopathic Hamsters

Benoît Vivien, MD^*, Jean-Stéphane David, MD, Jean-Luc Hanouz, MD, PhD, Julien Amour, MD^*, Yves Lecarpentier, MD, PhD, Pierre Coriat, MD^*, and Bruno Riou, MD, PhD^*||

*Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière, Université Paris VI, Paris, France; Department of Anesthesiology, CHU Edouard Herriot, Lyon, France; Department of Anesthesiology, CHU Côte de Nacre, Caen, France; Department of Physiology, CHU de Bicêtre, and Institut National de la Santé et de la Recherche Médicale, Palaiseau, France; and ||Department of Emergency Medicine, CHU Pitié-Salpêtrière, Université Paris VI, Paris, France

Address correspondence and reprint requests to B. Vivien, MD, Département d’Anesthésie-Réanimation, Centre Hospitalier Universitaire Pitié Salpêtrière, 47 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France. Address e-mail to benoit.vivien{at}psl.ap-hop-paris.fr

We investigated the effects of sevoflurane (0.7 to 3.6 vol%) on inotropy and lusitropy in left ventricular papillary muscles of healthy hamsters and genetically induced cardiomyopathic (strain BIO 14.6) hamsters in vitro (29°C, pH 7.40, Ca²⁺ 2.5 mM, stimulation frequency three per minute) under low (isotony) and high (isometry) loads. Sevoflurane induced a moderate positive inotropic effect in healthy hamsters (maximum unloaded shortening velocity and isometric active force at 3.6 vol%: 115% ± 12% and 128% ± 21% of baseline values, respectively; P < 0.01) and in cardiomyopathic hamsters (maximum unloaded shortening velocity and isometric active force at 3.6 vol%: 115% ± 20% and 124% ± 31% of baseline values, respectively; P < 0.05). This positive inotropic effect did not differ between healthy and cardiomyopathic hamsters, even when sevoflurane concentrations were corrected for minimum alveolar anesthetic concentration values in each strain, and was unchanged after - and ß-adrenoceptor blockade. After calcium-channel blockade, this positive inotropic effect was abolished in healthy hamsters but enhanced in cardiomyopathic hamsters. In both strains, sevoflurane induced a moderate negative lusitropic effect under low and high loads.

IMPLICATIONS: A paradoxical moderate positive inotropic effect of sevoflurane was observed in hamster ventricular muscle. This effect was likely related to calcium channel interaction, because after calcium-channel blockade, it was abolished in healthy hamsters and enhanced in cardiomyopathic hamsters.

This article has been cited by other articles:

				T. Barbry, M. Le Guen, V. De Castro, P. Coriat, B. Riou, and B. Vivien Minimum alveolar concentration of halogenated volatile anaesthetics in left ventricular hypertrophy and congestive heart failure in rats Br. J. Anaesth., December 1, 2007; 99(6): 787 - 793. [Abstract] [Full Text] [PDF]

				D. Breukelmann and P. R. Housmans Halothane, Isoflurane, and Sevoflurane Increase the Kinetics of Ca2+-Induced Conformational Change of Recombinant Human Cardiac Troponin C Anesth. Analg., February 1, 2007; 104(2): 332 - 337. [Abstract] [Full Text] [PDF]