JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vivien, B.
Right arrow Articles by Riou, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vivien, B.
Right arrow Articles by Riou, B.
Related Collections
Right arrow Cardiovascular
Right arrow Pharmacology

Anesth Analg 2002;95:31-38
© 2002 International Anesthesia Research Society

CARDIOVASCULAR ANESTHESIA

The Paradoxical Positive Inotropic Effect of Sevoflurane in Healthy and Cardiomyopathic Hamsters

Benoît Vivien, MD*, Jean-Stéphane David, MD{dagger}, Jean-Luc Hanouz, MD, PhD{ddagger}, Julien Amour, MD*, Yves Lecarpentier, MD, PhD§, Pierre Coriat, MD*, and Bruno Riou, MD, PhD*||

*Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Centre Hospitalier Universitaire (CHU) Pitié-Salpêtrière, Université Paris VI, Paris, France; {dagger}Department of Anesthesiology, CHU Edouard Herriot, Lyon, France; {ddagger}Department of Anesthesiology, CHU Côte de Nacre, Caen, France; §Department of Physiology, CHU de Bicêtre, and Institut National de la Santé et de la Recherche Médicale, Palaiseau, France; and ||Department of Emergency Medicine, CHU Pitié-Salpêtrière, Université Paris VI, Paris, France

Address correspondence and reprint requests to B. Vivien, MD, Département d’Anesthésie-Réanimation, Centre Hospitalier Universitaire Pitié Salpêtrière, 47 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France. Address e-mail to benoit.vivien{at}psl.ap-hop-paris.fr

We investigated the effects of sevoflurane (0.7 to 3.6 vol%) on inotropy and lusitropy in left ventricular papillary muscles of healthy hamsters and genetically induced cardiomyopathic (strain BIO 14.6) hamsters in vitro (29°C, pH 7.40, Ca2+ 2.5 mM, stimulation frequency three per minute) under low (isotony) and high (isometry) loads. Sevoflurane induced a moderate positive inotropic effect in healthy hamsters (maximum unloaded shortening velocity and isometric active force at 3.6 vol%: 115% ± 12% and 128% ± 21% of baseline values, respectively; P < 0.01) and in cardiomyopathic hamsters (maximum unloaded shortening velocity and isometric active force at 3.6 vol%: 115% ± 20% and 124% ± 31% of baseline values, respectively; P < 0.05). This positive inotropic effect did not differ between healthy and cardiomyopathic hamsters, even when sevoflurane concentrations were corrected for minimum alveolar anesthetic concentration values in each strain, and was unchanged after {alpha}- and ß-adrenoceptor blockade. After calcium-channel blockade, this positive inotropic effect was abolished in healthy hamsters but enhanced in cardiomyopathic hamsters. In both strains, sevoflurane induced a moderate negative lusitropic effect under low and high loads.

IMPLICATIONS: A paradoxical moderate positive inotropic effect of sevoflurane was observed in hamster ventricular muscle. This effect was likely related to calcium channel interaction, because after calcium-channel blockade, it was abolished in healthy hamsters and enhanced in cardiomyopathic hamsters.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
T. Barbry, M. Le Guen, V. De Castro, P. Coriat, B. Riou, and B. Vivien
Minimum alveolar concentration of halogenated volatile anaesthetics in left ventricular hypertrophy and congestive heart failure in rats
Br. J. Anaesth., December 1, 2007; 99(6): 787 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. Breukelmann and P. R. Housmans
Halothane, Isoflurane, and Sevoflurane Increase the Kinetics of Ca2+-Induced Conformational Change of Recombinant Human Cardiac Troponin C
Anesth. Analg., February 1, 2007; 104(2): 332 - 337.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.