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ANESTHETIC PHARMACOLOGY

Intravenous Verapamil Blunts Hyperdynamic Responses During Electroconvulsive Therapy Without Altering Seizure Activity

Zen’ichiro Wajima, MD PhD^*, Tatsusuke Yoshikawa, MD PhD^*, Akira Ogura, MD PhD^*, Kazuyuki Imanaga, MD^*, Toshiya Shiga, MD PhD, Tetsuo Inoue, MD PhD^*, and Ryo Ogawa, MD PhD^||

*Department of Anesthesia, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan; Department of Anesthesia, Hakujikai Memorial Hospital, Tokyo, Japan; Department of Anesthesiology, Tokyo Jikeikai Medical School, Tokyo, Japan; Center for Anesthesiology Research, The Cleveland Clinic Foundation, Cleveland, Ohio; and ||Department of Anesthesiology, Nippon Medical School, Tokyo, Japan

Address correspondence and reprint requests to Zen’ichiro Wajima, MD, PhD, Department of Anesthesia, Chiba Hokusoh Hospital, Nippon Medical School, 1715, Kamagari, Inba-mura, Inba-gun, Chiba 270-1694, Japan. Address e-mail to HFB01245{at}nifty.com

IMPLICATIONS: A dose of 0.1 mg/kg of verapamil, administered immediately before anesthesia, significantly reduces the increase in peak heart rate and mean arterial blood pressure after electroconvulsive therapy. Furthermore, the administration of verapamil does not reduce the duration of the seizure.