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ANESTHETIC PHARMACOLOGY

Issues in the Design and Interpretation of Minimum Alveolar Anesthetic Concentration (MAC) Studies

Department of Anesthesia and Perioperative Care, University of California, San Francisco

Address correspondence and reprint requests to James M. Sonner, MD, Department of Anesthesia and Perioperative Care, Room S-455i, Box 0464, University of California, San Francisco, CA 94143-0464. Address e-mail to sonnerj{at}anesthesia.ucsf.edu

IMPLICATIONS: The two experimental designs (quantal and bracketing) used for population minimum alveolar anesthetic concentration studies give equivalent results. An expression relating variability in terms of Hill coefficients and SD is presented. Evolutionary implications of low population variability in anesthetic phenotypes is discussed.

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