JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krieter, H.
Right arrow Articles by van Ackern, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krieter, H.
Right arrow Articles by van Ackern, K.
Related Collections
Right arrow Heart
Right arrow Resuscitation

Anesth Analg 2002;95:1031-1036
© 2002 International Anesthesia Research Society


CRITICAL CARE AND TRAUMA

Hypertonic-Hyperoncotic Solutions Reduce the Release of Cardiac Troponin I and S-100 After Successful Cardiopulmonary Resuscitation in Pigs

Heiner Krieter, MD DEAA*, Christof Denz, MD*, Christoph Janke, MD*, Thomas Bertsch, MD{dagger}, Thomas Luiz, MD*, Klaus Ellinger, MD*, and Klaus van Ackern, MD*

Institutes of *Anesthesiology and Intensive Care Medicine and {dagger}Clinical Chemistry, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany

Address correspondence and reprint requests to Heiner Krieter, MD, DEAA, Postfach 10 19 42, 68019 Mannheim, Germany. Address e-mail to heiner.krieter{at}anaes.ma.uni-heidelberg.de

In some patients, cardiopulmonary resuscitation (CPR) can revive spontaneous circulation (ROSC). However, neurological outcome often remains poor. Hypertonic-hyperoncotic solutions (HHS) have been shown to improve microvascular conductivity after regional and global ischemia. We investigated the effect of infusion of HHS in a porcine CPR model. Cardiac arrest was induced by ventricular fibrillation. Advanced cardiac life support was begun after 4 min of nonintervention and 1 min of basic life support. Upon ROSC, the animals randomly received 125 mL of either normal saline (placebo, n = 8) or 7.2% NaCl and 10% hydroxyethyl starch 200,000/0.5 (HHS, n = 7). Myocardial and cerebral damage were assessed by serum concentrations of cardiac troponin I and astroglial protein S-100, respectively, up to 240 min after ROSC. In all animals, the levels of cardiac troponin I and S-100 increased after ROSC (P < 0.01). This increase was significantly blunted in animals that received HHS instead of placebo. The use of HHS in the setting of CPR may provide a new option in reducing cell damage in postischemic myocardial and cerebral tissues.

IMPLICATIONS: Infusion of hypertonic-hyperoncotic solutions (HHS) after successful cardiopulmonary resuscitation in pigs significantly reduced the release of cardiac troponin I and cerebral protein S-100, which are sensitive and specific markers of cell damage. Treatment with HHS may provide a new option to improve the outcome of cardiopulmonary resuscitation.




This article has been cited by other articles:


Home page
Anesth. Analg.Home page
J. Bickenbach, N. Zoremba, M. Fries, R. Dembinski, R. Doering, E. Ogawa, R. Rossaint, and R. Kuhlen
Low Tidal Volume Ventilation in a Porcine Model of Acute Lung Injury Improves Cerebral Tissue Oxygenation
Anesth. Analg., September 1, 2009; 109(3): 847 - 855.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
A. Schneider, B. W. Bottiger, and E. Popp
Cerebral Resuscitation After Cardiocirculatory Arrest
Anesth. Analg., March 1, 2009; 108(3): 971 - 979.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
A. Larsson, M. Lipcsey, J. Sjolin, L.-O. Hansson, and M. B. Eriksson
Slight Increase of Serum S-100B During Porcine Endotoxemic Shock May Indicate Blood-Brain Barrier Damage
Anesth. Analg., November 1, 2005; 101(5): 1465 - 1469.
[Abstract] [Full Text] [PDF]




Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2002 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.