JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kolbitsch, C.
Right arrow Articles by Benzer, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kolbitsch, C.
Right arrow Articles by Benzer, A.
Related Collections
Right arrow Neuroanesthesia
Right arrow Monitoring (Non-cardiac)

Anesth Analg 2002;95:1049-1051
© 2002 International Anesthesia Research Society

NEUROSURGICAL ANESTHESIA

The Impact of Hypercapnia on Systolic Cerebrospinal Fluid Peak Velocity in the Aqueduct of Sylvius

Christian Kolbitsch, MD DEAA*, Ingo H. Lorenz, MD*, Christoph Hörmann, MD*, Michael F. Schocke, MD{dagger}, Christian Kremser, PhD{dagger}, Patrizia L. Moser, MD{ddagger}, Karl P. Pfeiffer, PhD§, and Arnulf Benzer, MD DEAA*

Departments of *Anaesthesia and Intensive Care Medicine, {dagger}Magnetic Resonance Imaging, {ddagger}Pathology, and §Biostatistics and Documentation, University of Innsbruck, Austria

Address correspondence and reprint requests to C. Kolbitsch, MD, DEAA, Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, A-6020 Innsbruck, Anichstr. 35, Austria. Address e-mail to christian.kolbitsch{at}uibk.ac.at

Phase-contrast magnetic resonance imaging measurements of systolic cerebrospinal fluid peak velocity (CSFVPeak) in the aqueduct of Sylvius have been shown to be sensitive enough to detect even minor changes in cerebral compliance. Clinically relevant changes in cerebral compliance can be caused by changes in cerebral blood volume (CBV). Changes in arterial carbon dioxide partial pressure, which correlate well with end-tidal carbon dioxide concentration (ETCO2), cause changes in CBV. In this study, we investigated the effect of hypercapnia-induced changes in CBV on systolic CSFVPeak in anesthetized patients (n = 8). Hypercapnia (ETCO2 = 60 mm Hg) increased systolic CSFVPeak in the aqueduct of Sylvius as compared with normocapnia (ETCO2 = 40 mm Hg) (hypercapnia: -5.67 ± 0.74 cm/s versus normocapnia: -3.54 ± 0.98 cm/s). In addition to the already known decrease in systolic CSFVPeak, changes in cerebral compliance can also prompt an increase in systolic CSFVPeak.

IMPLICATIONS: Magnetic resonance imaging measurements of systolic cerebrospinal fluid peak velocity (CSFVPeak) in the aqueduct of Sylvius are sensitive enough to detect even minor changes in cerebral compliance. We investigated the effect of hypercapnia-induced changes in cerebral blood volume on systolic CSFVPeak in anesthetized patients. Hypercapnia (end-tidal carbon dioxide concentration = 60 mm Hg) increased systolic CSFVPeak.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.