| JOURNAL HOME | CME HOME | THIS MONTH | PAST ISSUES | ETOC | COLLECTIONS |
| AUTHORS | REVIEWERS | EDITORIAL BOARD | FEEDBACK | RSS | HELP |
| ||||||||||||||
| ||||||||||||||
|
|
|
|
||||||||||||
|
||||||||||||||
*Department of Anesthesiology and Intensive Care Medicine, University Hospital of the Technical University of Dresden, Dresden, Germany; and Department of Anesthesiology, University Hospital of the Erasmus University Rotterdam, Rotterdam, The Netherlands
Address correspondence and reprint requests to Hermann J. Theilen, MD, Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, der Technischen Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Address e-mail to theilen{at}rcs.urz.tu-dresden.de
Hypertriglyceridemia is a possible unwanted effect during long-term propofol sedation while using a formulation containing long-chain triglycerides (LCT) from soybean oil. The use of propofol formulated in a solvent consisting of medium-chain triglycerides (MCT) and LCT might reduce the risk. Because a new solvent may affect the pharmacological profile of propofol, in this prospective, randomized, controlled, and double-blinded study we compared the pharmacodynamic and kinetic characteristics of propofol diluted in MCT/LCT fat solution with those of propofol formulated in LCT fat emulsion. In addition, serum triglyceride levels were measured during and after the administration of both drugs. Thirty patients likely to require mechanical ventilation over at least 48 h were randomized to receive either propofol 2% MCT/LCT (Group 1) or propofol 2% LCT (Group 2). Infusion rates of propofol (2.34 ± 0.83 mg · kg-1 · h-1 in Group 1 versus 2.31 ± 0.6 mg · kg-1 · h-1 in Group 2), the plasma propofol concentrations during infusion (0.95 ± 0.53 versus 0.98 ± 0.32 µg/mL), and the concentrations and arousal behavior after discontinuation of the drug did not show significant differences. Plasma triglyceride concentrations during sedation did not differ between the groups, whereas there was a tendency toward a more rapid triglyceride elimination in Group 1 after termination of the propofol administration.
IMPLICATIONS: Propofol diluted in an emulsion of medium- and long chain-triglycerides shows equivalent pharmacological properties during long-term sedation compared with its hitherto well known formulation containing long-chain triglycerides only. In addition, potential favorable effects on the plasma triglyceride profile could be found.
This article has been cited by other articles:
|
|
 |
|
  J. G. Bovill Anesthetic Pharmacology: Reflections of a Section Editor Anesth. Analg., November 1, 2007; 105(5): 1186 - 1190. [Full Text] [PDF]
|
|
|
|
|
|
M. Edanaga, M. Nakayama, N. Kanaya, N. Tohse, and A. Namiki Propofol Increases Pulmonary Vascular Resistance During {alpha}-Adrenoreceptor Activation in Normal and Monocrotaline-Induced Pulmonary Hypertensive Rats Anesth. Analg., January 1, 2007; 104(1): 112 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Sneyd Recent advances in intravenous anaesthesia Br. J. Anaesth., November 1, 2004; 93(5): 725 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Adam, J. van Bommel, M. Pelka, M. Dirckx, D. Jonsson, and J. Klein Propofol-Induced Injection Pain: Comparison of a Modified Propofol Emulsion to Standard Propofol with Premixed Lidocaine Anesth. Analg., October 1, 2004; 99(4): 1076 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Song, M. Hamza, P. F. White, K. Klein, A. Recart, and O. Khodaparast The Pharmacodynamic Effects of a Lower-Lipid Emulsion of Propofol: A Comparison with the Standard Propofol Emulsion Anesth. Analg., March 1, 2004; 98(3): 687 - 691. [Abstract] [Full Text] [PDF]
|
|
|
