This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a colleague Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Turan, A. Articles by Pamukçu, Z. Search for Related Content PubMed PubMed Citation Articles by Turan, A. Articles by Pamukçu, Z. Related Collections Regional Anesthesia Pharmacology

---

REGIONAL ANESTHESIA

Intravenous Regional Anesthesia Using Prilocaine and Neostigmine

A. Turan, B. Karamanloglu, D. Memis, G. Kaya, and Z. Pamukçu

Department of Anaesthesiology and Reanimation, Medical Faculty, Trakya University, Edirne, Turkey

Address correspondence and reprint requests to Alparslan Turan, Trakya Üniversity Tip Fakültesi, Anesteziyoloji ve Reanimasyon AD, 22030 Edirne, Turkey. Address e-mail to alparslanturan{at}yahoo.com

Neostigmine has been added to local anesthetics for central and peripheral nerve blocks resulting in prolonged, increased anesthesia and improved analgesia. We conducted this study to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Thirty patients undergoing hand surgery were randomly assigned to two groups to receive IVRA. The control group received 1 mL of saline plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL; the study group received 0.5 mg of neostigmine plus 3 mg/kg of prilocaine diluted with saline to a total dose of 40 mL. Sensory and motor block onset and recovery, anesthesia quality determined by an anesthesiologist, anesthesia quality determined by a surgeon, and dryness of the operative field were noted. Heart rate, mean arterial blood pressure, and oxygen saturation values were noted at 1, 5, 10, 20, and 40 min before surgery and after tourniquet release. Time to first analgesic requirement was also noted. Shortened sensory and motor block onset times, prolonged sensory and motor block recovery times, improved quality of anesthesia, and prolonged time to first analgesic requirement were found in the neostigmine group. We conclude that neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.

IMPLICATIONS: Neostigmine has been added to local anesthetics for central and peripheral nerve blocks. This study was conducted to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA). Neostigmine as an adjunct to prilocaine improves quality of anesthesia and is beneficial in IVRA.

This article has been cited by other articles:

				H. Sen, Y. Kulahci, E. Bicerer, S. Ozkan, G. Dagli, and A. Turan The Analgesic Effect of Paracetamol When Added to Lidocaine for Intravenous Regional Anesthesia Anesth. Analg., October 1, 2009; 109(4): 1327 - 1330. [Abstract] [Full Text] [PDF]

				S. Sen, B. Ugur, O. N. Aydin, M. Ogurlu, F. Gursoy, and O. Savk The analgesic effect of nitroglycerin added to lidocaine on intravenous regional anesthesia. Anesth. Analg., March 1, 2006; 102(3): 916 - 920. [Abstract] [Full Text] [PDF]