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Anesth Analg 2002;95:1772-1776
© 2002 International Anesthesia Research Society

GENERAL ARTICLES

Administration of Oxygen Before Tracheal Extubation Worsens Gas Exchange After General Anesthesia in a Pig Model

Alexander Loeckinger, MD, Axel Kleinsasser, MD, Christian Keller, MD, Andreas Schaefer, MD, Christian Kolbitsch, MD, Karl H. Lindner, MD, and Arnulf Benzer, MD

Department of Anesthesiology, Critical Care and Emergency Medicine, The Leopold-Franzens University Innsbruck, Austria

Address correspondence and reprint requests to Alexander Loeckinger, MD, Department of Anesthesiology, Critical Care and Emergency Medicine, The Leopold-Franzens University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Address e-mail to alex.loeckinger{at}uibk.ac.at

Administration of 100% oxygen before tracheal extubation is common clinical practice. We determined the effect of this technique on postoperative gas exchange in a porcine model using the multiple inert gas elimination technique. After general anesthesia with mechanical ventilation for a period of 30 min (inspiratory fraction of oxygen of 0.3), anesthesia was discontinued, and the pigs were randomized to an inspiratory fraction of oxygen of 0.3 or 1.0 until they could be safely extubated. Thirty minutes after extubation while breathing air, blood flow to poorly ventilated units had significantly increased in pigs that had been administered 100% oxygen as compared with those receiving 30% oxygen (17% ± 15% versus 7% ± 5%; P = 0.009). We conclude that exposure to 100% oxygen before extubation may cause an undesirable alteration in gas exchange.

IMPLICATIONS: Blood flow to lung units with a low VA/Q ratio was significantly larger in pigs that had been exposed to 100% oxygen before extubation as compared with those exposed to 30% oxygen before extubation.




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M. Renner, M. Hohlrieder, T. Wolk, F. Puhringer, A. T. Kleinsasser, C. Keller, and A. Benzer
Administration of 100% Oxygen Before Removal of the Laryngeal Mask Airway Does Not Affect Postanesthetic Arterial Partial Pressure of Oxygen
Anesth. Analg., January 1, 2004; 98(1): 257 - 259.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2002 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2002 by the International Anesthesia Research Society.