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ANESTHETIC PHARMACOLOGY

The Effects of Volatile Anesthetics on Nonadrenergic, Noncholinergic Depressor Responses in Rats

Daisuke Yoshikawa, MD^*, Masataka Kuroda, MD^*, Hiroshi Tsukagoshi, MD, Ken-ichiro Takahashi, MD^*, Shigeru Saito, MD^*, Koichi Nishikawa, MD^*, and Fumio Goto, MD^*

*Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Japan; and Department of Anesthesiology, Kameda General Hospital, Kamogawa, Japan

Address correspondence and reprint requests to Daisuke Yoshikawa, MD, Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. Address e-mail to yosikawa{at}med.gunma-u.ac.jp

The effects of volatile anesthetics on nonadrenergic, noncholinergic (NANC) transmission mediated by calcitonin gene-related peptide (CGRP) are unclear. We studied the effects of isoflurane, halothane, and sevoflurane on NANC depressor responses to electrical spinal cord stimulation in pithed rats whose mean arterial blood pressure was maintained near 120 mm Hg by continuous infusion of methoxamine. Autonomic outflow was blocked by hexamethonium. After 30 min of inhalation of different concentrations of anesthetics, spinal cord stimulation at the lower thoracic level (10 V at 4 Hz; duration, 1 ms) was applied for 30 s to induce a NANC depressor response. Isoflurane at 2% and halothane at 1.5% attenuated NANC depressor responses significantly, whereas isoflurane at 1%, halothane at 0.75%, and sevoflurane at 2% or 4% did not. Volatile anesthetics did not attenuate the release of CGRP after spinal cord stimulation, whereas isoflurane at 2% and halothane at 1.5% significantly inhibited depressor responses to exogenously administered CGRP. Sevoflurane at 4% did not significantly affect CGRP-induced depressor responses. Thus, isoflurane and halothane at large concentrations attenuate NANC depressor responses by attenuating the depressor action of CGRP, not CGRP release.

IMPLICATIONS: The anesthetics isoflurane and halothane attenuate nonadrenergic, noncholinergic depressor responses mediated by calcitonin gene-related peptide in the rat without affecting the release of the peptide.

This article has been cited by other articles:

				M. Kuroda, D. Yoshikawa, K. Nishikawa, S. Saito, and F. Goto Volatile Anesthetics Inhibit Calcitonin Gene-Related Peptide Receptor-Mediated Responses in Pithed Rats and Human Neuroblastoma Cells J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1016 - 1022. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999