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ANESTHETIC PHARMACOLOGY

Delayed Onset of Malignant Hyperthermia in Desflurane Anesthesia

Christian W. Hoenemann, MD^*,, Tobias B. Halene-Holtgraeve^*, Michael Booke, MD, PhD^*, Frank Hinder, MD, PhD^*, Fritz Daudel, MD^*, Alexander Reich, MD^*, and Hugo Van Aken, MD, PhD^*

*Department of Anesthesiology and Critical CareUniversitätsklinikum Münster, Münster; and Department of Anesthesiology and Critical CareMarienhospital Vechta, Vechta, Germany

Address correspondence and reprint requests to C. W. Hoenemann, Klinik und Poliklinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Münster, Albert Schweitzer Straße 33, 48129 Münster, Germany. Address e-mail to hoenemann@ anit.uni-muester.de.

IMPLICATIONS: Animal-experimental studies demonstrate desflurane’s trigger effect for malignant hyperthermia (MH). In contrast to other anesthetics, the time interval from exposure to the occurrence of symptoms is much longer with desflurane. This case report focuses on MH induced by desflurane alone.

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