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Anesth Analg 2003;96:58-61
© 2003 International Anesthesia Research Society

CARDIOVASCULAR ANESTHESIA

Citrated Blood Does Not Reliably Reflect Fresh Whole Blood Coagulability in Trials of In Vitro Hemodilution

A. M. Roche, FRCA, MMed (Anaes)*, M. F. M. James, FCA (SA), FRCA, PhD{dagger}, M. P. W. Grocott, BSc, MRCP, FRCA*, and M. G. Mythen, FRCA, MD*

*Centre for Anaesthesia, University College London, Middlesex Hospital, London, United Kingdom; and {dagger}Department of Anaesthesia, University of Cape Town Medical School, Cape Town, South Africa

Address correspondence and reprint requests to A. M. Roche, Centre for Anesthesia, University College London, First Floor Crosspiece, Middlesex Hospital, Mortimer Street, London W1T 3AA, UK. Address e-mail to tonyroche{at}doctors.org.uk

IMPLICATIONS: Citration and storage of whole blood markedly alter the Thrombelastograph® effects of hemodilution on coagulation. The results of hemodilution studies in which citrated blood has been used to study coagulation may not be reliable.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2003 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.