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Anesth Analg 2003;96:78-81
© 2003 International Anesthesia Research Society

PEDIATRIC ANESTHESIA

Oral Tramadol for the Treatment of Pain of 7–30 Days’ Duration in Children

John B. Rose, MD*, Julia C. Finkel, MD§, Adriano Arquedas-Mohs, MD||, Bruce P. Himelstein, MD{dagger}, Mark Schreiner, MD*{ddagger}, and Robert A. Medve, MD

Departments of *Anesthesiology and Critical Care Medicine, and {dagger}Oncology, Children’s Hospital of Philadelphia and the University of Pennsylvania, School of Medicine; {ddagger}Children’s Clinical Research Institute, Philadelphia, Pennsylvania; §Department of Anesthesiology, Children’s National Medical Center and George Washington University Medical Center, Washington, DC; ||Instituto Costarricense De Investigaciones Clinicas, Costa Rica; and ¶The R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey

Address correspondence and reprint requests to John B. Rose, MD, Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, 34th St. & Civic Center Blvd., Philadelphia, PA 19104. Address e-mail to rose{at}email.chop.edu

IMPLICATIONS: This open-label, multicenter trial was designed to determine the safety profile and analgesic efficacy of tramadol for the treatment of painful conditions lasting 7–30 days in 7–16-yr-old children. We found that tramadol 1–2 mg/kg per os every 4–6 h (maximal dose = 8 mg · kg-1 · d-1, not to exceed 400 mg/d) is a safe and effective analgesic in this patient population.




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 Journal of Pharmacy PracticeHome page
P. C. Walker and D. S. Wagner
Treatment of Pain in Pediatric Patients
Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275.
[Abstract] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.