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*Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany; and
Department of Anesthesia, University Hospital, Freiburg, Germany
Address correspondence and reprint requests to Prof. Dr. Joachim Boldt, Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr. 79, D-67063 Ludwigshafen, Germany. Address e-mail to BoldtJ{at}gmx.net
IMPLICATIONS: Articles on volume replacement published between 1981 and 2001 were analyzed. Albumin and gelatin do not predispose to development of kidney dysfunction. Modern hydroxyethyl starch (HES) solutions can be used safely in patients without kidney dysfunction even in large doses. Safety of HES in patients with preexisting altered kidney function still remains unclear.
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