JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akada, S.
Right arrow Articles by Ogawa, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akada, S.
Right arrow Articles by Ogawa, R.
Related Collections
Right arrow Monitoring (Non-cardiac)
Right arrow Pediatrics
Right arrow Pharmacology

Anesth Analg 2003;96:407-411
© 2003 International Anesthesia Research Society

PEDIATRIC ANESTHESIA

Salicylate Action on Medullary Inspiratory Neuron Activity in a Brainstem-Spinal Cord Preparation from Newborn Rats

Shinji Akada, MD, Shinhiro Takeda, MD, PhD, and Ryo Ogawa, MD, PhD

Department of Anesthesiology and Intensive Care, Nippon Medical School, Tokyo, Japan

Address correspondence and reprint requests to Shinhiro Takeda, MD, PhD, Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. Address e-mail to shinhiro{at}nms.ac.jp

Salicylate affects central respiratory control. The inspiratory neurons are the most important component of the medullary respiratory control center because they modulate the final motor output via the phrenic nerve. We investigated changes in burst rate, intraburst firing frequency, and membrane properties of inspiratory neurons in the isolated brainstem after the administration of salicylate. Newborn rat brainstem-spinal cord preparations were superfused with salicylate. Whole-cell recordings were performed from inspiratory neurons. Application of 1 mM salicylate caused an increase in the inspiratory neuronal burst rate from 6.9 ± 1.6 bursts/min to 8.2 ± 1.9 bursts/min (P < 0.05). The inspiratory neuron burst rate decreased from 8.3 ± 0.7 bursts/min to 4.5 ± 1.1 bursts/min after the application of 10 mM salicylate (P < 0.01). The depressant effect of 10 mM salicylate was antagonized by the {gamma}-aminobutyric acid (GABA) receptor antagonist bicuculline (1 µM). Resting membrane potential and intraburst firing frequency did not change with the application of salicylate and bicuculline even when the burst rate did change. We conclude that the effects of salicylate on the medullary inspiratory neurons are mainly due to a presynaptic action. GABAergic mechanisms are probably involved in the salicylate-induced central respiratory depression.

IMPLICATIONS: We investigated salicylate effects on the medullary respiratory center. Small-dose salicylate (1 mM) directly stimulated the respiratory center. Large-dose salicylate (10 mM) caused central respiratory depression involving a GABAergic mechanism.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Kashiwagi, Y. Okada, S.-i. Kuwana, S. Sakuraba, R. Ochiai, and J. Takeda
A Neuronal Mechanism of Propofol-Induced Central Respiratory Depression in Newborn Rats
Anesth. Analg., July 1, 2004; 99(1): 49 - 55.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.