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Anesth Analg 2003;96:755-756
© 2003 International Anesthesia Research Society

ANESTHETIC PHARMACOLOGY

The Induction of Apoptosis by Local Anesthetics: A Comparison Between Lidocaine and Ropivacaine

Emmanuel Boselli, MD*, Frédéric Duflo, MD*, Richard Debon, MD*, Bernard Allaouchiche, MD PhD*, Dominique Chassard, MD PhD{dagger}, Luc Thomas, MD PhD{ddagger}, and Jacques Portoukalian, PhD§

*{dagger}Department of Anesthesiology and Intensive Care, Hôpital de l’Hôtel-Dieu, Lyon; and {ddagger}§Laboratory of Glycobiology, Unité INSERM 346, Centre Hospitalier Lyon Sud, Pierre-Bénite, France

Address correspondence and reprint requests to Pr Dominique Chassard, Service d’Anesthésie-Réanimation, Hôpital de l’Hôtel-Dieu, 69002, Lyon, France. Address e-mail to dominique. chassard{at}chu-lyon.fr

IMPLICATIONS: This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2003 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.