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TECHNOLOGY, COMPUTING, AND SIMULATION

Intravenous Droperidol Causes a Reduction in the Bispectral Index in Propofol-Sedated Patients During Spinal Anesthesia

Masayasu Nakayama, MD^*, Noriaki Kanaya, MD^*, Hiromichi Ichinose, MD, Shuji Yamamoto, MD, and Akiyoshi Namiki, MD PhD^*

*Department of Anesthesiology, Sapporo Medical University School of Medicine; and Division of Anesthesia, Obihiro Kosei Hospital, Japan

Address correspondence and reprint requests to Masayasu Nakayama, MD, Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, Sapporo 060-8543, Japan. Address e-mail to mnakaya{at}sapmed.ac.jp

We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Another group of patients were sedated with a propofol infusion to maintain BIS at 60 ± 5 and were administered IV saline (placebo group; n = 20), droperidol 1 mg (dro-1 group; n = 20), or droperidol 2 mg (dro-2 group; n = 20) in a randomized order and in a double-blinded fashion. Although BIS remained the same in the conscious and placebo groups, it significantly decreased after administration of droperidol in the dro-1 and dro-2 groups. The decrease in BIS was significantly larger in the dro-2 group than in the dro-1 group. These results suggest that an antiemetic dose of droperidol enhances the hypnotic effect of propofol in a dose-dependent manner during spinal anesthesia.

IMPLICATIONS: An antiemetic dose of IV droperidol causes a decrease in the bispectral index in patients sedated with propofol during spinal anesthesia. We conclude that droperidol may enhance the hypnotic effect of propofol.

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