JOURNAL HOME CME HOME THIS MONTH PAST ISSUES ETOC COLLECTIONS
AUTHORS REVIEWERS EDITORIAL BOARD FEEDBACK RSS HELP
A&A International Anesthesia Research Society
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, B.-H.
Right arrow Articles by Cronin, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, B.-H.
Right arrow Articles by Cronin, A. J.
Related Collections
Right arrow Neuroanesthesia
Right arrow Monitoring (Non-cardiac)
Right arrow Pharmacology

Anesth Analg 2003;96:1155-1160
© 2003 International Anesthesia Research Society

NEUROSURGICAL ANESTHESIA

Preservation of the Cortical Somatosensory-Evoked Potential During Dexmedetomidine Infusion in Rats

Bai-Han Li, MD, Jeffrey S. Lohmann, MS CCC-A, CNIM, D.ABNM, H. Gregg Schuler, BA CCRC, and Arthur J. Cronin, MD

Department of Anesthesiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center

Address correspondence and reprint requests to Arthur J. Cronin, MD, 500 University Dr., H187, Hershey, PA 17033. Address e-mail to acronin{at}psu.edu

Successful somatosensory-evoked potential (SEP) monitoring has been performed during the administration of dexmedetomidine to patients, but a systematic investigation of the dose response of the SEP to dexmedetomidine has not been reported. In this study, we evaluated the effect of a range of dexmedetomidine doses on the cortical SEP in rats. Twelve rats were initially anesthetized with ketamine and the lungs were mechanically ventilated. Femoral arterial and venous catheters were placed. Anesthesia was maintained with constant infusions of remifentanil (5–15 µg · kg-1 · min-1) and vecuronium (56 µg · kg-1 · min-1). Dexmedetomidine was infused at 0.1, 0.25, 0.5, 1.0, and 2.0 µg · kg-1 · min-1 in a stepwise manner with 10-min infusion periods at each step. In eight rats, an additional large-dose infusion of dexmedetomidine at 10 µg · kg-1 · min-1 was administered for 30 min. The cortical SEPs were recorded after stimulation of the tibial nerve. At all infusion rates, there was a statistically insignificant increase in the SEP amplitude. Dexmedetomidine consistently increased the SEP latency, but these increases were not statistically significant. These data demonstrate that dexmedetomidine maintains technically adequate conditions for SEP monitoring in rats and provides support for future studies of the effect of dexmedetomidine on SEP monitoring in humans.

IMPLICATIONS: In rats, the administration of a wide range of infusion rates of dexmedetomidine did not significantly affect the somatosensory-evoked potential. These results suggest that dexmedetomidine might be a useful adjunctive drug in patients undergoing intraoperative somatosensory-evoked potential monitoring.




This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Yamamoto, M. Kawaguchi, M. Kakimoto, S. Inoue, and H. Furuya
The Effects of Dexmedetomidine on Myogenic Motor Evoked Potentials in Rabbits
Anesth. Analg., June 1, 2007; 104(6): 1488 - 1492.
[Abstract] [Full Text] [PDF]


Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.