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Anesth Analg 2003;96:1316-1319
© 2003 International Anesthesia Research Society

TECHNICAL COMMUNICATION

An Assessment of Different Filter Systems for Extracorporeal Elimination of Bivalirudin: An In Vitro Study

Andreas Koster, MD*, Derek Chew, MD{ddagger}, Marcus Gründel, MD*, Harald Hausmann, MD{dagger}, Onnen Grauhan, MD{dagger}, Herman Kuppe, MD*, and Bruce D. Spiess, MD§

Departments for *Anesthesia and {dagger}Thoracic and Cardiovascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany; {ddagger}Department of Cardiology, Flinders Medical Center, South Australia, Australia; and §Department of Cardiothoracic Anesthesia, Virginia Commonwealth University, Richmond, Virginia

Address correspondence and reprint requests to Dr. Andreas Koster, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany. Address e-mail to koster{at}dhzb.de

IMPLICATIONS: Bivalirudin is a new, direct thrombin inhibitor. We investigated the extracorporeal elimination rate of different hemofilters and one plasmapheresis filter for bivalirudin. Our data show that bivalirudin can be effectively eliminated via hemofiltration and plasmapheresis, although there were significant differences in the elimination rates among the filter systems investigated.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.