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PAIN MEDICINE

The Effect of Clonidine on Gastrointestinal Side Effects Associated with Ultra-Rapid Opioid Detoxification

Hong Ma, PhD MD^*, Jun Tang, MD^*, Paul F. White, PhD MD, FANCZA^*, Ronald H. Wender, MD, Thomas Leverone, MD, Rayond Quon, Scott Pearce, MD, Franklin Chiao, and Susan Erice, RN

*Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Texas; Department of Anesthesiology, Cedars-Sinai Medical Center; and Centinela Hospital Medical Center, Los Angeles, California

Address correspondence to Dr. Paul F. White, Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, F2.208, Dallas, TX 75390-9068. Address e-mail to paul.white{at}utsouthwestern.edu

IMPLICATIONS: Clonidine, an ₂-adrenergic agonist, is used to minimize withdrawal symptoms related to ultra-rapid opioid detoxification procedures. These preliminary data suggest that clonidine possesses dose-related antidiarrheal activity.

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