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Anesth Analg 2003;96:1413-1414
© 2003 International Anesthesia Research Society

PAIN MEDICINE

Large-Dose Intravenous Methotrexate-Induced Cutaneous Toxicity: Can Oral Magnesium Oxide Reduce Pain?

Santhanam Suresh, MD*,{dagger}, Sara Lozono, MD{ddagger}, and Steven C. Hall, MD*,{dagger}

Department of *Pediatric Anesthesiology, Children’s Memorial Hospital, and {dagger}Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and {ddagger}Division of Anesthesiology, The Cleveland Clinic Foundation, Cleveland, Ohio

Address correspondence and reprint requests to Santhanam Suresh, MD, Department of Pediatric Anesthesiology, Children’s Memorial Hospital, Box 19, 2300 Children’s Plaza, Chicago, IL 60614. Address e-mail to ssuresh{at}northwestern.edu

IMPLICATIONS: Chemotherapy for cancer is associated with pain including cutaneous vasculitis. Magnesium, an N-methyl-D-aspartic acid-receptor antagonist, was used successfully to treat an adolescent with pain caused by cutaneous vasculitis secondary to methotrexate therapy.






Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.