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PAIN MEDICINE

Large-Dose Intravenous Methotrexate-Induced Cutaneous Toxicity: Can Oral Magnesium Oxide Reduce Pain?

Santhanam Suresh, MD^*,, Sara Lozono, MD, and Steven C. Hall, MD^*,

Department of *Pediatric Anesthesiology, Children’s Memorial Hospital, and Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and Division of Anesthesiology, The Cleveland Clinic Foundation, Cleveland, Ohio

Address correspondence and reprint requests to Santhanam Suresh, MD, Department of Pediatric Anesthesiology, Children’s Memorial Hospital, Box 19, 2300 Children’s Plaza, Chicago, IL 60614. Address e-mail to ssuresh{at}northwestern.edu

IMPLICATIONS: Chemotherapy for cancer is associated with pain including cutaneous vasculitis. Magnesium, an N-methyl-D-aspartic acid-receptor antagonist, was used successfully to treat an adolescent with pain caused by cutaneous vasculitis secondary to methotrexate therapy.