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*Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy; and
Department of Pain Therapy and Intensive Care, National Cancer Institute "Regina Elena," Rome
Address correspondence and reprint requests to Dr. Sebastiano Mercadante, Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena, Cancer Center, Via S. Lorenzo 312, 90146, Palermo, Italy. Address e-mail to terapiadeldolore{at}la-maddalena.it
IMPLICATIONS: Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes.
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