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Anesth Analg 2003;97:264-267
© 2003 International Anesthesia Research Society

REGIONAL ANESTHESIA

Brugada-Type Electrocardiographic Pattern Induced by Epidural Bupivacaine

Nicole Phillips, MBBS*, Mark Priestley, MBBS FANCZA*, A. Robert Denniss, MD FRACP{dagger}, and John B. Uther, MD AO, MBBS, FRACP{dagger}

Departments of *Anesthesia and {dagger}Cardiology, Westmead Hospital, Westmead, Australia

Address correspondence and reprint requests to Nicole Phillips, Department of Anaesthesia, Level 3, Westmead Hospital, Westmead NSW 2145, Australia. Address e-mail to nicolephillips{at}optusnet.com.au

IMPLICATIONS: In this case report, we describe the postoperative occurrence of electrocardiogram changes suggestive for the Brugada syndrome in a patient receiving a continuous epidural bupivacaine infusion. After withdrawal of bupivacaine, the electrocardiogram changes were reversible. The patient’s history was unremarkable except for an incomplete right bundle branch block. We conclude that local anesthetics, particularly bupivacaine, have the potential to induce serious arrhythmias in patients with Brugada syndrome.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 2003 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 2003 by the International Anesthesia Research Society.