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ANESTHETIC PHARMACOLOGY

Stiff Person Syndrome and Anesthesia: Case Report

Jans Bouw, MD^*, Karin Leendertse, MD^*, Marina A. J. Tijssen, MD PhD, and Misa Dzoljic, MD PhD^*

*Departments of Anesthesiology and Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Address correspondence and reprint requests to J. Bouw, MD, Department of Anesthesiology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands. Address e-mail to j.bouw{at}amc.uva.nl

IMPLICATIONS: This case report describes the successful perioperative management of a patient with a rare and disabling neurologic disorder, the stiff person syndrome. The patient had a delayed emergence despite apparent full reversal of neuromuscular blockade. We suggest an interaction between the GABAergic effects of baclofen and volatile anesthetics as a possible cause.