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TECHNOLOGY, COMPUTING, AND SIMULATION

Hemispheric Synchronized Sounds and Intraoperative Anesthetic Requirements

Susan Dabu-Bondoc, MD^*, Jacqueline Drummond-Lewis, MD^*, Dorothy Gaal, MD^*, Maryanne McGinn, MA^*, Alison A. Caldwell-Andrews, PhD^*, and Zeev N. Kain, MD^*,,

Departments of *Anesthesiology, Pediatrics, and Child Psychiatry, Yale University School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut

Address correspondence and reprint requests to Zeev N. Kain, MD, Department of Anesthesiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510. Address e-mail to kain{at}biomed.med.yale.edu

Hemispheric synchronization is currently promoted as a treatment for preoperative anxiety and for reduction of intraoperative anesthetic and analgesic consumption. We designed this study to examine the effect of Hemisync® sounds on anesthetic hypnotic depth. After obtaining informed consent, we randomized subjects undergoing general anesthesia and outpatient surgery into two groups: the treatment group received Hemisync® sounds (n = 31), and the control group received a blank cassette tape (n = 29). Both groups received the intervention in the preoperative area and during the surgical procedure. Subjects underwent a propofol-based anesthetic regimen, and propofol doses required for the induction and maintenance of anesthesia were recorded. A bispectral index monitor was used to ensure that the hypnotic component of the anesthetic state was the same in all patients. We found no differences in the amount of propofol used during the induction of anesthesia (2.49 ± 0.59 mg/kg versus 2.60 ± 0.59 mg/kg; P = 0.48) or the maintenance of anesthesia (0.141 ± 0.02 mg · kg^-1 · min^-1 versus 0.146 ± 0.04 mg · kg^-1 · min^-1; P = 0.62) between the Hemisync® and control groups. We also found no differences between the Hemisync® group and the control group for participants with high state anxiety (P = not significant). We conclude that Hemisync® sounds do not reduce the hypnotic component of the anesthetic state of patients undergoing general anesthesia and surgery.

IMPLICATIONS: Hemisync®, a product marketed to reduce anesthetic consumption by synchronizing hemispheres of the brain, does not appear to reduce the anesthetic requirements of patients who undergo general anesthesia and surgery when depth of hypnosis is controlled by a bispectral index monitor.

This article has been cited by other articles:

				J. MacLaren and Z. N. Kain A Comparison of Preoperative Anxiety in Female Patients with Mothers of Children Undergoing Surgery Anesth. Analg., March 1, 2008; 106(3): 810 - 813. [Abstract] [Full Text] [PDF]

				S.-M. Wang, D. Gaal, I. Maranets, A. Caldwell-Andrews, and Z. N. Kain Acupressure and Preoperative Parental Anxiety: A Pilot Study Anesth. Analg., September 1, 2005; 101(3): 666 - 669. [Abstract] [Full Text] [PDF]

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999